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Showing 1 to 2 of 2 for “"ciliobrevins"”.
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Chemical Approaches to Dynein Inhibition
… small molecule antagonists of dynein, the ciliobrevins, have only recently been identified. As these compounds have suboptimal chemical properties and low potency, their use as probes for studying dynein has been limited. The work presented here describes a chemistry-based approach to …
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Chemical Biology of Dynein
… motor domain have been reported, such as ciliobrevins, dynapyrazoles and dynarrestin, but the inhibitor-binding site(s) have yet to be elucidated. Though inhibitor-bound dynein structures have been long-sought after, efforts have been curtailed by difficulties in obtaining high-resolution …