Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cigarette smoke extract"”.
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Effect of Cigarette Smoke Exposure on Bronchial Hyperresponsiveness in Mice and Response to a Corticosteroid and/or a β2-Adrenergic Agonist and Effect of Cigarette Smoke Extract on Cytokines Release from U937 Cells.
… reported that people with asthma who are active smokers show less improvement in lung function with corticosteroids compared to non-smokers.|Based upon these rationales, we wanted to develop a model of smoking and COPD in mice and to study response to inhaled corticosteroid (ICS) and/or long …
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Cigarette smoke and human pulmonary immune responses to mycobacteria
… to gain insights into the effects of exposure to cigarette smoke on human cells that form part of the innate immune system of host defence in the lung. The experiments on the pulmonary effects of cigarette smoke confirm that exposure has a significant effect upon innate host defences. Significant …
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The regulation of human airway epithelial expression of viperin by human rhinovirus
… chronic obstructive pulmonary disease (COPD). Cigarette smoke is the primary cause of COPD, and 25% of asthmatics smoke. Asthmatic subjects who smoke have more severe disease. Smokers also have more frequent and severe viral infections. Viperin is a novel antiviral molecule that is induced in …
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T-cells in COPD to help or harm? A study of T-cells in COPD patients and related aspects of T-cell function in vitro
… caused primarily by smoking and with increasing cigarette consumption in the world, the prevalence for COPD will most probably increase in the future. The chronic inflammation in the lungs of these patients is thought to drive the pathogenesis forward. Neutrophils, macrophages, T-cells and …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… or SIPS). Recent studies have shown that cigarette smoke extract induces senescence in lung fibroblasts and alveolar epithelial cells. 1,2,3,4-diexpoxybutane, or diepoxybutane (DEB), is the most reactive metabolite of 1,3-butadiene, an important hazardous air pollutant and potent genotoxic …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… effective. Linked with a significant history of cigarette smoking, pathology is characterised by recruitment of inflammatory cells to the lung (alveolar macrophages, neutrophils and lymphocytes: TH1 and CD8); dysregulated neutrophils and macrophages release tissue lysing proteases causing …
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NOVEL CINNAMIC ACID-BASED DEHYDROPOLYMERS FOR EMPHYSEMA: IN VITRO AND IN VIVO ASSESSMENT OF THEIR ACTIVITIES
… difficulty in breathing. It is caused mostly by cigarette smoking. However, its unresolved complex and multiple pathogenic mechanisms have left this disease without effective pharmacotherapy. This project hypothesized that cinnamic acid-based dehydropolymers (DHPs), originally discovered as novel …
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Nitric oxide in airway inflammation
… by smoking and glucocorticosteroids (GCS); 3) cigarette smoke could contribute to the EBC NOx concentration while it may also decrease FENO indirectly by converting airway NO to NOx. It was found that EBC volume was significantly correlated with both tidal volume and minute volume. Comparing …
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The effect of e-liquids and electronic cigarette vapour extract (ECVE) on key respiratory pathogens
In recent years, e-cigarettes have been marketed as an alternative to cigarette smoking that is less damaging to health. However, there is a lack of scientific evidence to support this assertation that they are a safer alternative to cigarettes. This study aimed to evaluate the effect of …