Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"cigarette smoke"”.
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Cigarette smoke and human pulmonary immune responses to mycobacteria
… to gain insights into the effects of exposure to cigarette smoke on human cells that form part of the innate immune system of host defence in the lung. The experiments on the pulmonary effects of cigarette smoke confirm that exposure has a significant effect upon innate host defences. Significant …
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Evaluation of non-invasive biomarkers for carcinogenic exposure to cigarette smoke
… as non-invasive biomarkers for exposure to cigarette smoke.;Methods. Volunteers, smokers ({dollar}\ge{dollar}20 cigarettes/day) and non-smokers (5 females + 6 males in each group), provided multiple urine samples. Urine samples from psoriasis patients undergoing coal tar therapy were also …
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The role of ceramides in cigarette smoke-induced alveolar cell death
… alveolar cell apoptosis. The mechanism by which cigarette smoke (CS) induces alveolar cell apoptosis is not known. We hypothesized that ceramides are induced by CS via specific enzymatic pathways that can be manipulated to reduce lung cell apoptosis. CS increased ceramides in the whole lung and …
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Measurement and Analysis of Cigarette Smoke Exposure and Smoking Behavior Using Wearable Sensors
Cigarette smoking is the most prevalent cause of preventable deaths in the whole world. There are hundreds of toxins in a single cigarette that can have harmful effects on both active and passive smokers. Researchers think it is important to understand and provide accurate information regarding …
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Investigating the Role of Cigarette Smoke and Alcohol in Oesophageal Squamous Cell Carcinoma
… The objective of this study was to investigate cigarette smoking and alcohol consumption as they have widely been reported as risk factors for OSCC. The project explored the impact of cigarette smoke condensate (CSC) treatment and EtOH on the expression of genes in cultured oesophageal cancer …
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Effect of Cigarette Smoke Exposure on Bronchial Hyperresponsiveness in Mice and Response to a Corticosteroid and/or a β2-Adrenergic Agonist and Effect of Cigarette Smoke Extract on Cytokines Release from U937 Cells.
… reported that people with asthma who are active smokers show less improvement in lung function with corticosteroids compared to non-smokers.|Based upon these rationales, we wanted to develop a model of smoking and COPD in mice and to study response to inhaled corticosteroid (ICS) and/or long …
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Cigarette Smoke Exposure in Drosophila Reveals Wnt-Mediated Remodeling of Airway Structure and Systemic Physiology
… injury, and impaired tissue repair, with cigarette smoke as its primary etiological factor. Increasing evidence implicates dysregulation of the Wnt signaling pathway in COPD pathogenesis, yet the distinct roles of canonical and non-canonical Wnt signaling in smoke-induced airway injury …
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Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
… mediators. While the response of HASMC to cigarette smoke exposure has been studied, the effects of sulfur dioxide on the cigarette smoke-induced inflammatory mediators have not. It has been proposed that sulfur dioxide creates a hypoxic state, similar to cigarette smoke, which suggested …
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Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
… mediators. While the response of HASMC to cigarette smoke exposure has been studied, the effects of sulfur dioxide on the cigarette smoke-induced inflammatory mediators have not. It has been proposed that sulfur dioxide creates a hypoxic state, similar to cigarette smoke, which suggested …
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Effects of Poor Quality Diets with Various Dietary Factors Added and Exposure to Cigarette Smoke on the Voluntary Alcohol Intakes of Albino Rats
… with various dietary additives and exposure to cigarette smoke in combination with poor quality diets. Male, Sprague-Dawley rats, from weanling age to 100 grams, were given the various experimental diets and a free fluid choice of ten per cent ethanol or tap water. Fluid intakes were recorded …
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Comparison of DNA adducts in mouse bladder and lung tissue from smoke-exposed and control mice
Smoking cigarettes is a common exposure pathway that has been linked with various types of cancer, including cancers of the lung and bladder. Carcinogens in the cigarette smoke may lead to the formation of DNA adducts within body tissues. DNA adducts arise from the covalent bond formed between a …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… or SIPS). Recent studies have shown that cigarette smoke extract induces senescence in lung fibroblasts and alveolar epithelial cells. 1,2,3,4-diexpoxybutane, or diepoxybutane (DEB), is the most reactive metabolite of 1,3-butadiene, an important hazardous air pollutant and potent genotoxic …
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Development and characterisation of air-liquid interface exposure systems for cell and tissue cultures
… and characterisation of in vitro aerosol and smoke exposure systems for future testing, the Vitrocell® 24/48 and the InHALES systems. Results: The Vitrocell® 24/48 system was developed to simulate physiological conditions at the air-liquid interface using a stagnation flow setup with …
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The Association of Specific EPHX1 and GSTM1 Gene Polymorphisms with Phenytoin- or Smoking-Associated Birth Defects
… Also, in utero exposure to the products of cigarette smoke leads to reduced birth weight, prematurity, and small but significant risk of oral clefts. Cleft lip/palate occur at a frequency of 1 per 750 to 1000 livebirths in the United States. Microsomal epoxide hydrolase (mEH) participates in …
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Roles of Oxidative Stress and Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression
… leukemia (AML) is a commonly diagnosed cancer in smokers. When current or former smokers have AML, they have worse survival compared to never smoking patients. This has been observed clinically for decades, but then it is unknown how smoking leads to worsened AML survival. Smoking causes oxidative …
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The regulation of human airway epithelial expression of viperin by human rhinovirus
… chronic obstructive pulmonary disease (COPD). Cigarette smoke is the primary cause of COPD, and 25% of asthmatics smoke. Asthmatic subjects who smoke have more severe disease. Smokers also have more frequent and severe viral infections. Viperin is a novel antiviral molecule that is induced in …
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Smoking and High-Fat Diet: Risk Factors Regulating Emphysema Formation
… the initiation and progression of this disease. Cigarette smoke has been known for a long time to be the major contributor to the development of emphysema. However, a possible impact of hypercholesterolemia on the destruction of alveoli has not been investigated. The work presented in this thesis …
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