Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"chronological lifespan"”.
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Roles of the TORC1 Signaling in Stress Response and Chronological Lifespan Extension in Yeast
… findings indicate that CR extends the healthy lifespan at least in part through downregulating the conserved target of rapamycin complex 1 (TORC1) pathway. In Saccharomyces cerevisiae, enhanced mitochondrial ROS signaling and hyper-accumulation of storage carbohydrates are the two major models …
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Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… defence systems, and ultimately the extension of chronological lifespan. These starvation-induced phenotypes were at least partially mediated by three classes of transcription factors (TFs), including the general stress response factors Msn2/4, the post-diauxic shift factor Gis1 and the heat-shock …
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A genome wide approach to stress response and chronological ageing in yeast
Caloric restriction (CR) extends lifespan from yeast to mammals. In budding yeast, inhibition of the conserved TOR and/or PKA pathways has been shown to mediate lifespan extension by CR partly through the activation of stress response. However, how the stress response is regulated at the systems …
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An Intermediate Heme Threshold is Necessary for the Activation of the Stress Response and Redox Homeostasis in Yeast
… of wild-type capacity) is necessary to promote chronological lifespan (CLS) extension via its dual roles in metabolic reprogramming to accumulate storage carbohydrates (trehalose and glycogen) and in the activation of the stress response to maintain homeostasis. The activation of the stress …