Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"chronic pancreatitis"”.
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Systematic mechanism-orientated approach to chronic pancreatitis pain
Contains fulltext : 144030.pdf (Publisher’s version ) (Open Access)
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Exploration of the Evidence to Support Clinical Practice to Decrease Hospital Readmission Rates For Patients With Chronic Pancreatitis
<p>Patients with chronic pancreatitis frequently require hospital readmission for complications of this debilitating disease. However, despite the negative impact on patients' quality of life and costs related to high utilization of health care resources, practice guidelines do not exist for …
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The role of type 2 innate lymphoid cells in the pathogenesis of pancreatitis
… characterised and their role in the pathology of pancreatitis remains unknown. The inflammatory influx associated with pancreatitis has been shown to have several type 2 immune features, including eosinophilia, and considering ILC2s are potent inflammatory mediators, this project addresses the …
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Synthesis towards Salvinorin Scaffold to Develop a Potential Pain Therapeutic and Selective, Potent Kappa Opioid Ligands
Effective chronic pain management has posed a challenge for patients who have sought after traditional therapy, opioid analgesics. Particularly in patients with chronic pancreatitis, traditional therapy has failed to assist with pain management causing daily activity to be an even bigger challenge. …
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Integrin alpha6beta4 contributions in pancreatic adenocarcinoma
… (PanIN) lesions, pancreatic adenocarcinomas, and chronic pancreatitis. In normal pancreatic ducts, integrin alpha6beta4 was noted only at the cell’s basal interface with the basement membrane. In pancreatic adenocarcinomas, 92% (104/113) demonstrated overexpression of integrin alpha6beta4 and …
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Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide
… were assayed in patients with acute pancreatitis, chronic pancreatitis and maturity-onset diabetes mellitus.
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Pancreatic fluid collections : towards a classification to facilitate treatment selection
… distinguishes PFCs according to the associated pancreatitis, being acute or chronic. This was based on definitions established at the Atlanta Symposium in 1992. The chronic pancreatitis related pseudocysts were further selected anatomically into intra or extra pancreatic.
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Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation
Background: TPIAT may relieve pain from chronic pancreatitis while minimizing diabetes risk. Avoiding hyperglycemia minimizes islet apoptosis during engraftment. Closed Loop therapy may improve glycemic control in this population. Methods: Analysis of 14 patients (36% male; age 35.9±11.4 years) at …
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The Functional Contribution of Adaptive Immunity In The Biology of Pancreatic Cancer and Therapeutic Targeting of Oncogenic Kras
… of our study, we determine how the presence of pancreatitis alters the TME and the course of progression of PDAC. A significant portion of PDAC patients have been reported to present with underlying chronic pancreatitis and bile duct obstruction. However, current therapeutic strategies do not …
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Tabagismo como fator de risco para pancreatite crônica – revisão sistemática de literatura.
… dos termos Smoking, Smoke, com Tobacco, Pancreatitis, Chronic Pancreatitis e Alcoholic Pancreatitis, com emprego de operadores booleanos específicos nos bancos de dados: SCOPUS, PUBMED e LILACS. Foram incluídos no estudo artigos do tipo coorte em inglês, publicados nos últimos dez anos …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
Chronic pancreatitis (CP) is an irreversible disease process defined by acinar cell necrosis, inflammation and fibrosis. With disease progression, patients develop pancreatic insufficiency secondary to the destruction of functional pancreatic tissue and its replacement with scarring. Patients with …
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… fibrosis is a constant pathological feature of chronic pancreatitis and the hyperactive stroma associated with pancreatic cancer. Strong evidence supports an important role of cyclooxygenase-2 (COX-2) and COX-2 generated prostaglandin E2 (PGE2) during pancreatic fibrosis. Pancreatic stellate …
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Novel markers for human T regulatory cells in healthy donors and cancer patients
… isolated from the blood of healthy donors (HDs), chronic pancreatitis (CP), malignant pancreatic cancer (PC) and liver metastases from colorectal cancer (LI/CRC) patients. PBMCs were then stained with anti-CD3, anti-CD4, anti-GARP, anti-LAP, anti-Helios, anti-FoxP3, anti-IFN-γ, and anti-IL-10 …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… transplantation to treat type 1 diabetes and chronic pancreatitis.
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A study of a multi-systemic immune-mediated disease in the English Cocker Spaniel
Chronic pancreatitis (CP) is a common disease in the English Cocker Spaniel (ECS) and shows a distinctive clinical and histopathological appearance. It is characterised by duct destruction, interlobular fibrosis, dense periductular and perivenous lymphocytic aggregates, the presence of multi-organ …
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Connective Tissue Growth Factor in Pancreatitis
Pancreatitis is an inflammatory condition of the pancreas in which pancreatic acinar cells (PAC) become injured by noxious agents and produce pro-inflammatory mediators. Excessive alcohol consumption is a major cause of pancreatitis in the West. Acute pancreatitis (AP) can be recurrent and severe, …
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Fabrication of Lspr-Based Multiplexed and High-Throughput Biosensor Platforms for Cancer and Sars-Cov-2 Diagnosis
… a large cohort (n=110) of pancreatic cancer and chronic pancreatitis patient samples.