Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"chronic neuropathic pain"”.
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A Pre-Clinical Assessment of Minocycline For Treatment of Chronic Neuropathic Pain After Spinal Cord Injury
… with a spinal cord injury (SCI) often develop chronic neuropathic pain (CNP). Unfortunately, the clinically approved, current standard of treatment, gabapentin, only provides temporary pain relief. This treatment can cause numerous adverse side effects that negatively affect the daily lives of …
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Heme Oxygenase-2 as a novel target to treat inflammation and chronic neuropathic pain associated with corneal injury and surgery
… with the trans-section of basal nerve, is pain, which typically occurs within the first 72 h after surgery. Topical ocular nonsteroidal anti-inflammatory drugs (NSAIDs) has demonstrated efficacy in controlling pain after surgery and they are commonly used during the postoperative period. …
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Reactive Oxygen Species and Lipid Peroxidation Products Contribute to Neuropathic Pain in Chronic Spinal Cord Injured Rats
… of locomotion, sexual and bladder function, and chronic neuropathic pain. A rat model of spinal cord injury was used to study the mechanisms of chronic neuropathic pain. Chronically up-regulated reactive oxygen species (ROS) generated in neurons as a result of spinal cord injury contribute to the …
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Sensorimotor Recovery, Functional and Structural Brain Plasticity, and the Development of Chronic Pain Following Upper Limb Peripheral Nerve Transection and Microsurgical Repair
… impairments, a proportion of which also develop chronic neuropathic pain. Individual psychological factors may contribute to the development, intensity and duration of chronic pain. Furthermore, a large body of evidence has indentified beneficial and maladaptive cortical plasticity following …
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Prostaglandin EP3 receptor signalling as a contributor to sex differences in stress-related disorders mediated by the locus coeruleus
Stress and pain are deeply interconnected phenomena, with acute stress triggering adaptive responses, whereas chronic stress and chronic neuropathic pain lead to persistent alterations in neural circuits regulating affective and sensory processing. These processes are tightly interlinked at …
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Kratom Alkaloid Mitragynine: Therapeutic Role and Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
Chronic neuropathic pain is a leading cause of disability worldwide and is associated with immense economic burden. Of all chronic neuropathic pain conditions, chemotherapy-induced peripheral neuropathy (CIPN) persists as a monumental public health crisis, as it is the most common comorbidity among …
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Acrolein as a novel therapeutic target for spinal cord injury induced neuropathic pain
… years of research, post-spinal cord injury (SCI) chronic neuropathic pain remains refractory to treatment and drastically impairs quality of life for SCI victims beyond paralysis. Although inflammation and free radicals contribute to neuropathic pain in SCI, the mechanism is not completely clear. …
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Neural Correlates of Inter-Individual Differences in Pain Processing Investigated by Functional Magnetic Resonance Imaging of the Entire Central Nervous System
The experience of pain is a highly complex and personal experience, characterized by tremendous inter-individual variability. Pain perception can differ substantially across individuals due to many factors such as age, gender, genetics, cognition and emotionality etc. Some individuals are very …
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NTS2-selective analogs as an alternative treatment to chronic pain
Chronic pain is a major health problem affecting 20% of the world population. Consequently, this medical condition represents an enormous burden on the quality of life and mental health of affected patients, not to mention the astronomical cost to the economy and healthcare systems. Mild analgesics …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
Neuropathic pain caused by peripheral nerve damage results in ectopic neuronal excitability, primary sensory neuron degeneration, loss of inhibition by spinal GABAergic neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. …
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Neural Mapping of Pain and Addiction: Visualizing Dopaminergic Modulation in the Mesocorticolimbic System
… and cocaine. To visualize the nuances of chronic pain treatment and VTA activity, we incorporate our CMOS imaging platform to investigate the effect of morphine on the VTA response during acute nociceptive stimulation in chronic neuropathic pain adult mouse models. Our findings suggest a …
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The role of the periaqueductal gray in modulation of acute and chronic pain: Actions of drugs with analgesic properties on periaqueductal gray neuronal network
… actions within modulatory pathways for pain, The PAG is a critical nucleus in these pain networks and receives and sends extensive projections within these networks. Chronic pain is a major side effect in 30-70% of cancer patients receiving chemotherapeutic regimen. Endocannabinoids, …
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Cannabis for medical use in rare diseases
Rare diseases (RDs) are severe and usually chronically debilitating and RD patients often lack effective and accessible treatment options. Medicinal Cannabis (MC) is used for symptoms such as pain, spasticity, nausea and vomiting, seizures and anxiety which may be experienced by RD patients. The …
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Effects of Omega-3s and Vitamin E Prophylactic Diets and the Implications of Lipid Transport in Spinal Cord Injury
… paralysis, spasticity, and significant chronic neuropathic pain. The trauma leads to significantly increased levels of free radical and oxidative stress that contribute to obstructing tissue healing and recovery. A growing body of evidence shows that administration of hydrophobic …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
… is strongly associated with the development of chronic neuropathic pain, particularly in women. This pain represents a clinically significant component of CIPN, yet pharmacological treatments to manage it effectively remain limited, underscoring the need to elucidate the underlying …