Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"chronic morphine"”.
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The Impact of Chronic Morphine on Adult Hippocampal Progenitor Cells and the Neurogenic Niche
… proliferation and neurogenesis are decreased by chronic morphine, yet how this alteration occurs is unknown. It is unclear if morphine causes alterations in cell cycle progression, progenitor cell maturation, or indirectly inhibits progenitor cells by altering the hippocampal neurogenic niche. I …
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The Impact of Opioids and Opiates on Adult Hippocampal Neurogenesis
… to develop more effective means of treatment. Chronic morphine and heroin have previously been shown to decrease proliferation and survival of progenitor cells in the adult rat and mouse hippocampus. Here, I show that endogenous opioids may act through the mu opioid receptor (MOR) to similarly …
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People with chronic non-cancer pain receiving chronic morphine treatment at the Chronic Pain Management Clinic of Groote Schuur Hospital: a cross-sectional survey of characteristics and satisfaction with treatment
Introduction Chronic pain is an ever-growing burden whose complex nature and interpatient variability make management challenging. Evidence for the use of chronic opioids for the treatment of chronic non-cancer pain is controversial with limited data to support its long-term efficacy. The use of …
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Molecular Mechanisms of Opioid Use Disorder in Human Brain Models
… induced pluripotent stem cell model of neuronal morphine exposure, I identify gene expression caused by chronic morphine exposure and compare these expression signatures to the source subjects’ brain.</p> <p>Integrating results from all studies, I propose a hypothesis whereby opioid use disorder …
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The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
… of cFos and CRE- mediated transcription to chronic morphine administration and opiate antagonist-precipitated morphine withdrawal. Additionally, orexin knockout mice and C57BL/6J mice that received a selective OX1R antagonist develop attenuated morphine dependence, as indicated by a less …
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Codeine, heightened pain sensitivity and medication overuse headache: a neuroimmune hypothesis and novel treatment strategy.
… worldwide. It relies upon partial metabolism to morphine to elicit analgesic effects. Paradoxically, the pain-reliever morphine has previously been linked to states of increased pain sensitivity; such as medication overuse headache and opioid-induced hyperalgesia and allodynia. Despite the …
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EFFECTS OF MU OPIOID RECEPTOR AGONISTS ON INTRACRANIAL SELF-STIMULATION IN THE ABSENCE AND PRESENCE OF “PAIN” IN RATS
… at the mu receptor (methadone> fentanyl> morphine> hydrocodone> buprenorphine> nalbuphine) and compared their effects on ICSS in the absence (phase one) or presence (phase 2) of pain. Adult male Sprague-Dawley rats were equipped with intracranial electrodes targeting the medial forebrain …