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Showing 1 to 20 of 32 for “"chronic lymphocytic leukaemia"”.
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Characterisation of genetic complexity in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia in the Western world, characterised by the accumulation of mature B-cells. The disease has a heterogeneous course whereby some patients do not require treatment for several years while others follow a more aggressive disease …
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Functional role of ZAP70 in Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is the most common type of leukaemia. It is common in older people and rare in people under 40. CLL is characterised by the accumulation of monoclonal CD5+CD23+ B lymphocytes in the blood, bone marrow and secondary lymphatic tissues. There are 2 main subtypes of …
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The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia
Chronic Lymphocytic Leukaemia (CLL) is the most common adult Leukaemia in the UK, Western Europe and America. It is a malignancy of naive B-cells. The clinical course of patients with CLL is heterogeneous; some patients survive for years without treatment, others die of a chemotherapy resistant …
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CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
… in the development and progression of chronic lymphocytic leukaemia (CLL) is currently of major interest. Pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) represent exogenous and endogenous microenvironmental factors acting via a range of receptors, …
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An investigation of T cell dysregulation in B-cell chronic lymphocytic leukaemia
B-cell chronic lymphocytic leukaemia (B-CLL) is characterized by an accumulation of clonal malignant B cells within lymphoid tissue, the bone marrow and the peripheral blood. Whilst abnormalities of these B cells are the essential cause of this disease, the aim of this research project was to …
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The detection and clinical significance of TP53 dysfunction in chronic lymphocytic leukaemia.
Standard therapy for patients with chronic lymphocytic leukaemia involves the use of DNA damaging drugs. If the cellular DNA damage response has been compromised then these standard therapies will be ineffective at inducing apoptosis. Central to this response is the protein, p53. Loss of the …
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Niche disturbances in Chronic Lymphocytic Leukaemia affect HSC residency and drug resistance
Chronic lymphocytic leukaemia (CLL) is an indolent B cell malignancy infiltrating the lymphatic system and invariably the bone marrow (BM). Although treatment options for patients with advanced disease have significantly increased in the past years and improved life-expectancies, the disease …
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Clinical Decision Support System with Adaptive Software Framework for Chronic Lymphocytic Leukaemia Cell Classification
… and a tailored wrapper design pattern for chronic lymphocytic leukaemia (CLL) cell classification. The system goes through a sequence of steps while working with the lymphocyte images: it segments the lymphocyte with average segmentation accuracy of (97% ±0.5 for lymphocyte nucleus and …
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The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)
Chronic lymphocytic leukaemia (CLL) is characterised by a progressive accumulation of mature CD5+CD20+CD23+ lymphocytes. Despite the remarkable progress in our understanding of the immunobiology of CLL, the aetiology of the disease remains unknown. The consensus is that CLL cells are driven by …
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A study of the role of ATM mutations in the pathogenesis of B-cell chronic lymphocytic leukaemia
Mutations in the ATM gene have previously been identified in CLL tumours. In this project, I have demonstrated that their detection would have prognostic value. With a prevalence of 12%, ATM mutations represent the commonest single gene defect to be detected in CLL tumours and they identified a …
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In Vitro Studies of the Anti-Leukaemic Activity of Bezafibrate and Medroxyprogesterone Acetate Against Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world, and continues to have very low cure rates. The bulk of the tumour cells are non-cycling peripheral cells that accumulate from a minority of dividing cells within proliferation centres (PCs), located the lymph …
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Evaluation of TP53 and IGHV clinical molecular prognostic testing for patients with Chronic Lymphocytic Leukaemia at Tygerberg Hospital
Introduction: Chronic lymphocytic leukaemia (CLL) is a monoclonal, lymphoproliferative malignancy with variable clinical outcomes and treatment responses, largely influenced by genetic and molecular factors. Among these, genomic DNA sequence variants in the tumour suppressor gene p53 (TP53) and …
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Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL)
Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in the western world and remains incurable. It is driven by as yet unknown (auto)antigens via the B cell receptor (BCR) and growth, survival and expansion signals it receives from the microenvironment through a range of cytokines and …
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Ανάλυση λεμφοκυτταρικών υποπληθυσμών στην χρόνια λεμφογενή λευχαιμία με χρήση μονοκλωνικών αντισωμάτων: Προγνωστική σημασία ανοσολογικών παραμέτρων
… parameters in 41 newly diagnosed patients with chronic lymphocytic leukaemia (CLL) and correlated these findings with the clinical data and the subsequent course of the disease. The ratio of helper to supressor T cells (CD4/CD8), the proportion of circulating natural killer (nk) cells and the nk …
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Changes of nucleosome positioning and 3D chromatin organization in cell transitions
… blood of healthy individuals and patients with chronic lymphocytic leukaemia.
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In Our Blood: Mapping Narrative Enactments of Leukaemia Online
… invisible, and currently considered incurable, chronic lymphocytic leukaemia (CLL) presents with variable progression outcomes from indolent, through actively progressive, to terminal in some cases. Diagnosed with CLL myself, and having learned much of what I know about my disease online, this …
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Analysis of the Tumour Microenvironment in CLL
… understanding of complex cellular systems in Chronic Lymphocytic Leukaemia (CLL).CLL is a cancer of the blood which affects B cells. CLL cells accumulate quickly in the body but die rapidly by apoptosis when cultured in the lab, suggesting that CLL cell survival can be modulated by tumour cell …
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Pan-Cancer Analysis of Non-Coding Driver Mutations
… carcinoma and the aggressive subtype of chronic lymphocytic leukaemia (CLL). The mutation also confers an adverse prognosis to CLL patients independently. This finding demonstrates the first non-coding driver in spliceosomal RNAs, reveals a novel mechanism of aberrant splicing in cancer …
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