Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"chronic inflammatory disease"”.
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) which is thought to arise from a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in …
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Prevalence of interleukin-1 polymorphisms and its association with periodontal disease status in the Xhosa population of South Africa
Periodontitis is a bacterially induced chronic inflammatory disease that destroys the supporting tissues of teeth. Clinical observations and experimental evidence indicates that there is a genetic influence of risk factors for periodontitis. A specific pattern of IL-1 polymorphisms (known as the …
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Subgrouping Ulcerative Colitis Patients using Administrative Claims Data
… have been diagnosed with Ulcerative Colitis, a chronic inflammatory disease affecting the colon. Uncovering patient subgroups could improve treatment guidelines and help physicians choose an appropriate treatment plan for a patient. Here, we outline a Python implementation to generate a cohort …
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Effect of non-surgical periodontal therapy on the anaemic status of patients with periodontitis: A systematic review
Periodontitis is a chronic inflammatory disease resulting in progressive destruction of the tissues supporting the teeth (Hajishengallis and Chavakis, 2021). There is ever increasing evidence in the literature of the link between periodontitis and systemic diseases. The periodontal disease …
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Expanding Allergen-specific Tr-1 CD4+ T cells to treat Allergic Asthma
Asthma is a chronic inflammatory disease of the lungs, which is one of the most frequent chronic disease in industrialized nations. The associated morbidity and occasional mortality rates are secondary to an underlying dysfunction of the airway driven by immune-mediated inflammation. Our lab has …
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Factors That Influence Monocyte Differentiation and Hematopoietic Stem Cell Recruitment In Atherogenesis
<p>Atherosclerosis is a disease characterized by the infiltration of monocytes into the vessel wall, their differentiation into phagocytic resident macrophages, and subsequent lipid uptake and accumulation causing plaque growth and atheroma formation. Hyperlipidemia and other risk factors for …
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Comparison of Behcet's Disease and Recurrent Aphthous Ulcer According to Characteristics of Gastrointestinal Symptoms
Behcet's disease (BD) is a multisystemic chronic inflammatory disease. It is characterized by recurrent oral and genital ulcers, uveitis, skin lesions and other manifestations, including central nervous system, vascular, arthritis, and gastrointestinal ulcers of variable severity. Recurrent …
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Impacto da hipovitaminose D em pacientes adultos asmáticos: uma revisão da literatura
Asthma is a chronic inflammatory disease, characterized by reduced airflow and hyperresponsiveness of the lower airways, with bronchial edema, exaggerated mucus production and smooth muscle hypertrophy. It has several causal factors that can aggravate it, and a more current proposal is that poor …
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The unfolded protein response and HLA-B27 misfolding: implications for ankylosing spondylitis
… substrate HLA-B27 is highly associated with the chronic inflammatory disease ankylosing spondylitis (AS) and has a tendency to misfold in the ER. Here, we show that overexpression of HLA-B27 and non-disease associated HLA-B7 in immortalised cell lines leads to heavy chain misoxidation, which is …
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The biomechanical analysis of the hand in rheumatoid arthritis patients with MCP arthroplasty
Rheumatoid arthritis (RA) is a chronic inflammatory disease, causing extreme deformity, pain and swelling of joints, severely affecting quality of life. Arthroplasty has had considerable success in larger joints such as the hip. The most frequently used artificial finger joints rely on a silicone …
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Models of the Mucosal Inflammatory and Regulatory Immune Pathways: The Role of Host Response in Microbial Persistence and Pathogenesis
… with experimental data gathered about the disease process following infection. In this era of unprecedented amounts of data and information for various disease models, the creation and articulation of such hypothesis are often beyond human capacity. Modeling offers a means to generate …
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The role of seminal plasma in the regulation of inflammation and inflammatory pathways in the cervix: potential for cervical cancer progression and HIV transmission in South African women
Cervical cancer is a chronic inflammatory disease of multifactorial etiology accounting for an annual estimated 266,000 deaths worldwide and usually present in sexually active women. In sub-Saharan Africa, cervical cancer is the most common cancer among women and the leading cause of cancer related …
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Analysis of plasminogen binding to Treponema denticola, a key periopathogen
Periodontitis is a chronic inflammatory disease that affects over 116 million adults in the United States. A shift in the normal microflora occurs as periodontal disease develops resulting in a larger number of Gram-negative anaerobes and spirochetes. An increase in the oral spirochete, Treponema …
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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
Allergic asthma is a chronic inflammatory disease that affects approximately 300 million people worldwide. The health problem is compounded by the fact that the prevalence of the disease is increasing in the Western world. Thus, there is a continued need for new and improved therapies for the …
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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
Allergic asthma is a chronic inflammatory disease that affects approximately 300 million people worldwide. The health problem is compounded by the fact that the prevalence of the disease is increasing in the Western world. Thus, there is a continued need for new and improved therapies for the …
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Immune Responses Aginst Aldehyde Modified Extracellular Matrix in Atherosclerosis
Atherosclerosis is a chronic inflammatory disease and the leading cause of myocardial infarction and stroke. Accumulation, aggregation and subsequent oxidation of LDL in the arterial wall are considered as key events in the development of atherosclerosis. The oxidation of LDL generates reactive …
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Periodontal bacterial-DNA initiated immuno-inflammatory responses in human osteoblastic cells
Periodontitis is a chronic inflammatory disease initiated by gram negative anaerobic bacteria. These bacteria possess pathogen-associated molecular patterns (PAMPs) that interact with various receptors including Toll like receptors (TLRs). Bacterial DNA (bDNA) is one of the PAMPs mainly recognized …
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Regulation of Tumor Necrosis Factor-alpha Signaling in Rheumatoid Arthritis Synovial Fibroblasts by Green Tea Polyphenol Epigallocatechin-3-gallate
Rheumatoid arthritis (RA) is a chronic inflammatory disease, which affects about 1% of the population. It occurs when cytokines, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α, stimulate synovial fibroblast proliferation leading to joint damage and destruction. …
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The role of lipid laden macrophages in airways disease
Asthma is a chronic inflammatory disease of the airway and is often associated with Gastro-Oesophageal Reflux (GOR). Lipid laden macrophages (LLM) in the airway have previously been reported indicative of aspiration secondary to GOR. We hypothesised that lipid droplets from undigested or partially …
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