Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"chronic infections"”.
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The Anaemias of Chronic Infections
The changes occurring in the red blood cells in infective illnesses are amongst the least carefully studied problems of haematology. In spite of the fact that these anaemias are extremely common, it is different to find adequate literature to make possible even a clear description of the blood …
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Mathematical Models of Underlying Dynamics in Acute and Chronic Immunology
… later immune responses. When comparing acute infections to chronic infections, there are also differences in the dynamics of the immune system. In this dissertation, we develop three mathematical models to explore these differences in the immune response to acute and chronic infections through …
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A cystic fibrosis infection monitor
P. aeruginosa causes chronic infections in people with the inherited disorder, cystic fibrosis (CF). These chronic infections result in a high rate of morbidity and mortality. Once established, the infections are almost impossible to eradicate. Pulmonary exacerbations, thought to be caused by P. …
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Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition
… small colony variants (SCVs) are associated with chronic infections, yet the mechanisms by which these variants acquire iron are unknown. Mutation of hemB, involved in heme biosynthesis, generated a stable SCV that was auxotrophic for hemin and formed small colonies on solid media. To support …
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Synthesis and biological research of the pseudomonas aeruginosa signaling compounds PQS and N-3-oxo-dodecanoyl-L-homoserine lactone
… complex host-pathogen interactions involved in chronic infections, the Pseudomonas aeruginosa signaling molecules 3-oxo-C12-homoserine lactone and Pseudomonas quinolone signal were synthesized so that the mammalian cellular responses to their presence via an infection could be studied. It was …
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Experimental evolution of Burkholderia cenocepacia biofilm populations
… found on many natural surfaces and in long-term, chronic infections. Here we describe the parallel evolution of cooperative communities derived from a clone of Burkholderia cenocepacia during approximately 1500 generations of biofilm selection. This long-term evolution was enabled by a new …
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Investigating the DNA damage response induced by Typhoid Toxin
… 27 million cases of typhoid fever per year and chronic infections, which retain the pathogen in the population. The toxin is secreted by intracellular Salmonella into the extracellular milieu from where it enters bystander cells and causes DNA damage through its putative nickase activity. …
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Effects of Surface Topography on Bacterial Biofilm Formation
… antimicrobial agents, biofilms are the cause of chronic infections associated with implanted medical devices such as breast implants, orthopedic devices, pace markers, and many others. Besides the prevalence, biofilm infections are associated with high mortality, presenting an urgent need for …
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Structural and Functional Studies of Sensor Kinase RetS from Pseudomonas aeruginosa and Peptidoglycan Hydrolase SleB from Bacillus anthracis
… Pseudomonas aeruginosa causes both acute and chronic infections in predisposed individuals. Acute infections require a functional Type Three Secretion System (TTSS), which mediates the translocation of select cytotoxins into host cells. Chronic infections, the leading cause of death among …
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MODELING REORGANIZATION OF PCF10-INDUCED COMPLEX STRUCTURES IN ENTEROCOCCUS FAECALIS UNDER ERYTHROMYCIN TREATMENT
… wide range of illnesses including persistent or chronic infections. In this dissertation, we look at the bacterium Enterococcus faecalis. E. faecalis is a gram-positive, commensal bacterium commonly found in the human gastrointestinal tract. Generally, commensal E. faecalis does not negatively …
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Modulation of macrophage metabolism and function by the helminth peptide FhHDM-1
… response, to prevent expulsion and establish chronic infections. Understanding how they achieve this offers a therapeutic strategy for the treatment of human diseases which are caused by unregulated inflammation. Previous characterisation of the liver fluke’s secreted proteins identified a …
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Non-invasive optical quantification of otitis media and middle ear effusions
… membrane of patients with normal, acute, and chronic infections in an attempt to identify differentiating characteristics of each infection state. Following this work, algorithms were developed to identify and quantify middle ear effusions. Lastly, the development of a second-generation …
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
Human papillomaviruses (HPV) typically cause chronic infections by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the …
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THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY
… types. The establishment of diseases, such as chronic infections and cancers, is attributed to severe loss of or dysfunctions of CD4+ T cells. Even in acute infections, CD4+ T cell deficiency leads to poor memory responses. While the role of CD4+ T cells is being increasingly appreciated in …
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The role of PLK1 in Hepatitis B Virus (HBV) infection of the liver
With 250 million reported chronic infections globally, Hepatitis B Virus (HBV) is a major human health issue, linked to increased risk for development of hepatocellular carcinoma (HCC). Current treatments to control chronic HBV infection remain ineffective. New and effective therapies that target …
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NOVEL STRATEGIES TO DEVELOP BETTER BRUCELLOSIS VACCINES USING BRUCELLA ABORTUS RB51 AND B. NEOTOMAE
… intracellular coccobacilli that can cause chronic infections in several mammals. Brucella spp. can exhibit a smooth or rough phenotype; smooth Brucella spp. contain a surface-exposed O-polysaccharide in their cell wall structure while the rough Brucella spp. are devoid of the …
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Rational development of novel small molecule leads against the transcriptional activator protein ExsA of Pseudomonas aeruginosa
… so because it is a common cause of nosocomial infections. Burn victims and cystic fibrosis patients are particularly vulnerable to P. aeruginosa infections. The pathogen is highly virulent, and consequently it is a leading cause of death in intensive care units, especially among cases of …
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Highly Saturated Transposon Sequencing identifies genes impacting Staphylococcus aureus pathogenesis in macrophages
… host cell types,facilitating its persistence in chronic infections. The genes contributing to intracellular pathogenesis have not yet been fully enumerated. Here, we cataloged genes influencing S. aureus invasion and survival within human macrophages using two laboratory strains (ATCC2913 and …
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Characterization of a Novel Sensing Mechanism Governing Antigenic Variation in P. Falciparum
… to evade the human immune system and cause chronic infections. The molecular mechanisms that control activation and silencing of individual var genes, as well as coordination of the switching process, presently remain incompletely defined. P. falciparum contains only ~60 var gene family …
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Determining the impact of Heligmosomoides polygyrus infection on the development of colitis
… of H.polygyrus infection, with both acute and chronic infections resulting in the same phenotype. Helminth exacerbated DSS colitis is characterised by significant bacterial translocation to the spleen, which is concluded to be due to loss of intestinal epithelial integrity. Helminth infection …
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