Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"chronic immune activation"”.
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… therapy (ART) and are associated with chronic immune activation and oxidative stress within the systemic circulation and central nervous system (CNS). Pathological studies of post-mortem brain parenchyma indicate productive HIV replication in brain macrophages/microglia and restricted …
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Enhancement of Hiv Persistence By Adipose Tissue
… becomes dormant and protected from drugs and immune responses. The major tissue reservoirs for HIV include lymphoid tissues such as lymph nodes, bone marrow, and gastrointestinal lymphoid tissues, but adipose tissues could potentially harbor HIV as well. Adipose tissues are ubiquitous …
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A mouse model for the pathogenesis of immunodeficiency virus infection
… infection, which is characterized by progressive immune deficiency attributable to a slow but relentless depletion of CD4+ T cells, the main viral targets. HIV infection is also associated with increased T cell turnover and a state of generalized immune activation. One of the fundamental questions …
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Blood-Based Inflammation Biomarkers of Neurocognitive Impairment in People Living with HIV
Race and sex minorities are disproportionately affected by HIV in the United States. Approximately 50% of people living with HIV (PLWH) experience HIV-associated neurocognitive disorders (HAND). ART has decreased incidence of HAD but the less severe forms of HAND has increased. Diagnosis of HAND is …
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Characterizing the cellular latent reservoir of HIV-1 and the effect of immune activation on characteristics of the reservoir
… majority of PLWH only initiated treatment in chronic infection. Since early ART is known to restrict formation of the latent reservoir of HIV-1, research in both early and late ART initiators is necessary. This research focused on characterising the viral reservoir in South African women in a …
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The epidemiology of Chronic Non-Communicable Diseases (NCDS) and NCD risk factors in adolescents & youth living with HIV in Cape Town, South Africa
… face an elevated NCD risk resulting from chronic immune activation, psychosocial factors and the complications of long-term antiretroviral therapy (ART). However, there is data paucity on the intersection of NCDs and HIV in adolescents in South Africa and Africa. This thesis aims to …