Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"chronic hepatitis"”.
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Health Utilities in People with Chronic Hepatitis C
Background: Hepatitis C virus infection is associated with reduced quality of life. One way to measure the quality of life of hepatitis C patients is using health utilities. Health utilities provide insight into not only the state of a patient’s health but also the strength of preference for that …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
BACKGROUND: Hepatitis C virus (HCV) has infected 170 million people worldwide and is a leading cause of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. Liver injury and disease progression in hepatitis C virus infection is driven by the host immune response. Previous …
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Clonal proliferation of hepatocytes during chronic hepatitis B virus infection.
Chronic hepatitis B virus (HBV) infection causes liver disease that can progress to cirrhosis and hepatocellular carcinoma (HCC). Changes in the hepatocyte population that occur from the early immune-tolerant stage of infection to late-stage disease outcomes remain unclear. We hypothesised that …
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The severity and activity of liver disease in chronic hepatitis C infection
Infection with hepatitis C virus (HCV) is the cause of 90% of cases of non -A, non -B hepatitis. Chronic HCV hepatitis is at least initially an asymptomatic illness, but a proportion of patients will develop symptomatic, complicated disease. The most common complications are hepatic cirrhosis and …
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Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B
… significant inflammation in patients with chronic hepatitis B (CHB). DESIGN AND METHODS: Between October 2005 and June 2009, 384 subjects with CHB were enrolled. RESULTS: Multiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide …
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EVALUATION OF THE HEPATIC MICROENVIRONMENT BEFORE AND AFTER ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C
Hepatitis C virus (HCV) infection remains a substantial global health burden, affecting millions annually despite recent therapeutic advances. Direct-acting antiviral (DAA) therapies have transformed clinical management, achieving cure rates exceeding 90% and significantly reducing complications …
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Measuring liver stiffness using transient elastography in the non-invasive assessment of chronic hepatitis B
… method to assess liver fibrosis in patients with chronic hepatitis B (CHB). The present thesis set out to determine the application of liver stiffness measurement in patients with CHB, including the long-term longitudinal changes and its prognostic value. In a study of 1,268 CHB patients, liver …
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Association between Chronic Hepatitis B Virus Infection and Interleukin-10, Tumor Necrosis Factor-α Gene Promoter Polymorphisms
The reasons for the viral persistence of hepatitis B virus (HBV) infection are unknown, but are probably related to host immune factors. Cytokines play significant roles in inflammatory and immune defense. This study was undertaken to investigate the association between HBV infection and …
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Caspase-cleaved fragments of cytokeratin-18 as a marker of inflammatory activity in chronic hepatitis B virus infection
… diagnosis between inactive carrier and active hepatitis is important in patients with chronic hepatitis B (CHB) virus infection. Serum cytokeratin (CK)-18 fragments (M30 antigen) are proposed as biomarkers of apoptosis. We investigated whether serum M30 levels might help to characterize the …
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Association of Lamivudine-Resistant Mutational Patterns with the Antiviral Effect of Adefovir in Patients with Chronic Hepatitis B
… and -negative Groups 8 C. Baseline hepatitis B virus polymerase mutations 8 D. Effect of lamivudine-resistant mutational pattern on the virologic and biochemical response to adefovir 12 IV. DISCUSSION 15 V. CONCLUSION 18 REFERENCES 19 국문요약 24 "
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Development and characterization of an in vitro culture system as a physiological model for chronic Hepatitis B infection
Human Hepatitis B virus (HBV) is the prototype member of the family Hepadnaviridae that consists of enveloped, partially double stranded DNA viruses that specifically target hepatocytes for viral replication. Although a vaccine has been available for more than 20 years chronic HBV infection …
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To Stop or Not to Stop: Response After Nucleos(t)ide Analogue Withdrawal Among Patients With Chronic Hepatitis B
Hepatitis B virus (HBV) infection is a major global public health concern with high morbidity and mortality due to progression of liver disease to cirrhosis, liver failure, and hepatocellular carcinoma (HCC). Nucleos(t)ide analogues (NAs) are highly effective in viral suppression however, most …
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Association of HBV DNA and ALT Level with YMDD motif Mutation Type in Lamivudine Resistance for Chronic Hepatitis B
BACKGROUND: The emergence of lamivudine resistant hepatitis B virus(HBV), with point mutation in the YMDD motif of DNA polymerase gene, has been reported in chronic hepatitis B patients with lamivudine treatment. The aim of this study was to investigate the distribution patterns and clinical …
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Factors affecting initial virologic response and emergence of resistant mutants after adefovir treatment in lamivudine resistant chronic hepatitis B patients
… inhibits both wild-type and lamivudine-resistant hepatitis B virus replication. The development of adefovir resistance is delayed and infrequent compared with lamivudine resistance. The aim of this study was to characterize the serologic, biochemical and virologic response to adefovir, and to …
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Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models
The most common risk factors for chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) include chronic alcohol abuse and infection with hepatitis B (HBV) or hepatitis C (HCV) virus. Growing evidence from human studies and experimental models suggests that pre-degenerative and …
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An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection
Hepatitis B virus (HBV) is oncogenic and a major cause of hepatocellular carcinoma (HCC) in the developing world. It integrates parts of its genome such as the HBx gene, core and surface antigens into the human genome. The integrated viral DNA disrupts gene function resulting in physiological …
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Using Statistical Techniques and Machine Learning to Assess Potential Biomarkers and Clinical Characteristics for Differences between Chronic Hepatitis C Virus and Hepatocellular Carcinoma
Hepatitis C virus (HCV) belongs to a family of viruses that infect and inflame the liver. Severity of HCV infection ranges from mild illness lasting a few weeks (acute) to lifelong liver injury resulting in fibrosis (chronic). Approximately 75%–85% of people infected with hepatitis C virus will …
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Chronic hepatitis at Groote Schuur Hospital: 1978-1996 : a literature review of the syndrome, its clinical spectrum and management at Groote Schuur Hospital
Chronic hepatitis has multiple aetiologies which include viral hepatitis (hepatitis B, B+D and C), autoimmune hepatitis and drugs. In sub-Saharan Africa the major aetiological factor is chronic hepatitis B virus infection. In this region 10-15% of the population is chronically infected with the …
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Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение
… of their application in 205 patients with chronic hepatitis C virus infection: liver biopsy with assessment of necroinflammatory activity and fibrosis; automatic morphometric analysis with calculation of the area of fibrosis; clinical and laboratory indicators for non-invasive determination …
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