Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 133 for “"chronic exposure"”.
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Neuropsychological function as a result of chronic exposure to methadone and other opioids
It is increasingly recognised that chronic exposure to opioids has been associated with neuropsychological impairment during both active use and following a period of abstinence. The overall objective of this thesis was to review the relevant prior literature in a systematic manner and subsequently …
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Chronic exposure of mice to propylparaben enhances inflammatory response and promotes uterine fibrosis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Dysfunction of Pancreatic INS-1 Beta-Cells Induced by Chronic Exposure to High Glucose
"배경 및 목적 : 제2형 당뇨병은 전 세계적으로 가장 흔하고 심각한 대사 질환이다. 정상인의 췌장베타세포는 혈중 포도당 농도 조절에 중요한 인슐린을 합성 및 분비하는 중요한 역할을 수행하고 있다. 현재 베타세포의 기능이상은 인슐린 저항성과 함께 제2형 당뇨병을 유발시키는 중요한 병인으로 인식되고 있다. 포도당은 베타세포의 기능을 조절하는 가장 중요한 조절자로서 특히 베타세포의 인슐린 유전자 발현과 생합성, 분비에 중요한 역할을 하고 있다. 그러나 포도당이 고농도로 오랫동안 베타세포에 노출될 때, 베타세포의 기능이상을 초래하며, …
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The effect of chronic exposure to endurance exercise on the skeletal muscle of distance runners
… of this thesis was to examine the effects of chronic exposure to endurance running on the athlete, with particular emphasis on skeletal muscle.
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Effects of chronic exposure to ibuprofen and naproxen on Florida flagfish (Jordanella floridae) over one complete life-cycle
… organisms. This research investigated the chronic effects of waterborne exposure to 0, 0.1, 1, 10 and 100 μg/L of a nonselective and selective NSAID (ibuprofen and naproxen, respectively) on Florida flagfish (Jordanella floridae) over one complete life-cycle. Chronic exposure concentrations …
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Circadian desynchrony in the mouse: how does chronic exposure to rotating shift work-like patterns of light/dark affect circadian rhythms and neurobehavioural outcomes
Disruption of circadian rhythms is associated with several deleterious health consequences, increased prevalence of obesity, maladaptive changes in affect, and cognitive impairment. Still it is estimated that as much as 20% of the work force are exposed to this risk factor experiencing some degree …
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The Effects of Chronic Nitrite Exposure on Tissue Morphology and Physiology in Xiphophorus couchianus
… damage in aquatic species in acute, short term, exposures. However, it is unknown how chronic exposure to contemporary water nitrite concentrations can affect fish physiology. Moreover, there is a lack of current knowledge on how nitrite effects maternal health and, consequently, embryo health …
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Economic and policy implications of urban air pollution in the United States, 1970 to 2000
… (after 2000) from reduction in mortality due chronic exposure during these years. The economic benefit of those saved mortalities is another $7 trillion using a 3% discount rate. Another calculation is the remaining economic burden of unmitigated pollution levels (actual historical pollution). …
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Effects of ibuprofen on Rainbow Trout (Oncorhynchus mykiss) following acute and chronic waterborne exposures
… this experiment was to determine the acute and chronic effects of ibuprofen on rainbow trout (Oncorhynchus mykiss). Cyclooxygenase (COX) activity, vitellogenin (VTG) concentration and ethoxyresorufin-O-deethylase (EROD) activity were evaluated following waterborne ibuprofen exposure of trout to …
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The Impact of Gamma Stimulation on Neurological Phenotypes of Alzheimer's Dementia and Down Syndrome
… in patients with mild AD during acute and chronic exposure to GENUS. Additionally, due to the increase in amyloid burden and other shared biological and cognitive phenotypes present in the setting of trisomy 21 compared to AD, we also present initial investigation into the use of GENUS in …
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Ultrastructural characterization of ultraviolet induced corneal disease : an animal model
… century therapeutic benefits of sunlight exposure were beginning to be understood and by the end of the nineteenth century the importance of ultraviolet radiation was being realized. Danish physician Niels Finsen, whom many regard as the father of ultraviolet phototherapy, also stressed …
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MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING
Alcoholism is a chronically relapsing disorder characterized by an inability to remain abstinent from alcohol for prolonged periods of time. One of the major factors contributing to relapse is the development of profound anxiety during abstinence. Our lab has previously demonstrated that chronic …
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Exposure to Synthetic Antioxidants Disrupt Early Development in the Frogs Silurana Tropicalis and Lithobates Pipiens
… into the environment yet their toxic acute and chronic effects on humans and wildlife are not well understood. Some of these chemicals behave as endocrine disruptors (EDCs), altering development in many wildlife species including amphibians, which are sensitive to these compounds. Producing …
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Chronic oxidative stress and susceptibility to renal carcinogenesis
… objective was to evaluate effect of H2O2-induced chronic oxidative stress on neoplastic transformation of normal human kidney epithelial cells. To achieve our study goals, we developed an in-vitro cell model by exposing the HK-2 cells (immortalized normal human kidney epithelial cells) to H2O2 for …
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The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium
Recent epidemiological data has indicated that chronic exposure to metals such as arsenic and cadmium increases the risk of cancer and other diseases. These metals may have negative biological effects on cells by disrupting homeostatic cellular processes and altering normal signal transduction. One …
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Never Smokers -- Are They More Sensitive to the Respiratory Health Effects of Ambient Air Pollution?
… between ambient air pollution and incident chronic obstructive pulmonary disease (COPD) using the spatial interpolation method from the three nearest fixed monitoring stations to residence and workplace. However, few studies have assessed the risk of death among disease specific subgroups …
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Impact of Corticosterone and Zinc Deprivation on Memory and Hippocampal Functioning
… study was to examine the impact of long-term exposure to corticosterone (CC) and chronic zinc-deprivation (ZnD) on memory performance and hippocampal damage in rats. Previous work has examined the impact of exposure to CC or the impact of ZnD, but no previous work has examined the combined …
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The effect of environmental temperature on exercise metabolism
… stress leads to an earlier onset of fatigue. Chronic exposure to hot conditions, however, may reverse this process. Exercise in cool conditions can either improve or reduce exercise tolerance depending on the severity of the environmental temperature and/or the intensity of the exercise. …
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Mercury Uptake by Wild Rice Plants in Northern Minnesota
… were consistent for the six lakes. Using a chronic exposure formula and the highest THg and MeHg concentrations in finished rice grains, it was determined that the toxicity in wild rice grains in Minnesota is extremely low.
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