Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"chronic cerebral hypoperfusion"”.
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Investigating the role of TREM2 and neuroinflammation in an experimental model of chronic cerebral hypoperfusion
Chronic cerebral hypoperfusion resulting from cerebrovascular disease is associated with the development of white matter damage, cognitive impairment and dementia. Although incompletely understood, recent studies suggest neuroinflammation is a key mechanism driving vascular pathology, white matter …
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Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion
… to this hypothesis, cerebrovascular (e.g. chronic cerebral hypoperfusion) and molecular (e.g. APOE, epigenetics) factors might contribute to age-related white matter pathology and cognitive decline. To test this, I used a new mouse model of chronic cerebral hypoperfusion and examined the …
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Investigation of inflammatory and oxidative stress mechanisms in the disruption of white matter structure and function following chronic cerebral hypoperfusion
… by cerebrovascular disease and disturbances in cerebral blood flow delivery. It is the second leading form of dementia and vascular factors such as hypertension, diabetes and obesity are associated with an increased risk of developing VCI. White matter alterations are a prominent pathological …
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Effects of Sex and Aging in the Response to Global Cerebral Hypoperfusion
… 15- 40% of all dementia cases. Reductions in cerebral blood flow from intracranial and extracranial atherosclerosis increase VCID risk, even in the absence of overt clinical or imaging evidence of stroke/embolization. The pathology seen in patients with chronic cerebral hypoperfusion, such as …
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Mixed Dementia Induced by Right Common Carotid Artery Occlusion in an Alzheimer Mouse Model
… with Alzheimer disease (AD), the effect of chronic cerebral hypoperfusion (CCH) on the progression of AD has not been widely evaluated. We aimed to evaluate whether CCH would aggravate the behavioral changes and plaque formation in an AD transgenic (Tg) mouse model. Female Tg2576 (Tg+) mice …
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THE EFFECT OF MELATONIN IN PROTECTING AGAINST THE BEHAVIORAL CONSEQUENCES OF CHRONIC HYPOPERFUSION IN MIDDLE-AGED FEMALE RATS
… occlusion (2VO) procedure in rats, which limits cerebral blood flow (CBF) through bilateral arterial ligation. Therefore, the current study investigated whether chronic melatonin would attenuate 2VO induced behavioral deficits in middle-aged female rats. Thirty 9- to 11-month-old female …