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Showing 1 to 2 of 2 for “"chronic carriage"”.

  1. The molecular epidemiology of Salmonella Typhi and applications for policy

    … that the first H58 organism was generated during chronic carriage. The subsequent increased use of fluoroquinolones led to several independent mutations in gyrA, leading to decreased fluoroquinolone susceptibility. The apparent ability of H58 to acquire and maintain AMR genes continues to pose a …

    cambridge Repository record for The molecular epidemiology of Salmonella Typhi and applications for policy (opens in a new tab)

  2. Investigating the DNA damage response induced by Typhoid Toxin

    … 27 million cases of typhoid fever per year and chronic infections, which retain the pathogen in the population. The toxin is secreted by intracellular Salmonella into the extracellular milieu from where it enters bystander cells and causes DNA damage through its putative nickase activity. …

    cambridge Repository record for Investigating the DNA damage response induced by Typhoid Toxin (opens in a new tab)