Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"chronic Hepatitis C"”.
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Health Utilities in People with Chronic Hepatitis C
Background: Hepatitis C virus infection is associated with reduced quality of life. One way to measure the quality of life of hepatitis C patients is using health utilities. Health utilities provide insight into not only the state of a patient’s health but also the strength of preference for that …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
BACKGROUND: Hepatitis C virus (HCV) has infected 170 million people worldwide and is a leading cause of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. Liver injury and disease progression in hepatitis C virus infection is driven by the host immune response. Previous …
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The severity and activity of liver disease in chronic hepatitis C infection
Infection with hepatitis C virus (HCV) is the cause of 90% of cases of non -A, non -B hepatitis. Chronic HCV hepatitis is at least initially an asymptomatic illness, but a proportion of patients will develop symptomatic, complicated disease. The most common complications are hepatic cirrhosis and …
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EVALUATION OF THE HEPATIC MICROENVIRONMENT BEFORE AND AFTER ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C
Hepatitis C virus (HCV) infection remains a substantial global health burden, affecting millions annually despite recent therapeutic advances. Direct-acting antiviral (DAA) therapies have transformed clinical management, achieving cure rates exceeding 90% and significantly reducing complications …
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Using Statistical Techniques and Machine Learning to Assess Potential Biomarkers and Clinical Characteristics for Differences between Chronic Hepatitis C Virus and Hepatocellular Carcinoma
Hepatitis C virus (HCV) belongs to a family of viruses that infect and inflame the liver. Severity of HCV infection ranges from mild illness lasting a few weeks (acute) to lifelong liver injury resulting in fibrosis (chronic). Approximately 75%–85% of people infected with hepatitis C virus will …
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Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение
… of their application in 205 patients with chronic hepatitis C virus infection: liver biopsy with assessment of necroinflammatory activity and fibrosis; automatic morphometric analysis with calculation of the area of fibrosis; clinical and laboratory indicators for non-invasive determination …
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Thrombozytenantikörper bei Hepatitis-C-Infektion für die Diagnose einer Autoimmunthrombozytopenie
… examine, if thrombocytopenia in patients with a chronic hepatitis C virus infection is caused through specific platelet autoantibodies. Which influence has the therapy with alpha-interferon on the development of platelet antibodies? Does the viral load, the HCV-genotype and the state of fibrosis …
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Fatigue und Lebensqualität bei Patienten mit chronischer Hepatitis C
… life and is often observed with patients with a chronic liver illness. The objective of this work is to examine the fatigue symptom and its influence on the quality of life, psychic load and cognitive abilities with patients with chronic hepatitis C. In the present study 46 patients with chronic …
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Heterozygote Hämochromatose-Genmutationen als genetische Progressionsfaktoren bei chronischer Hepatitis C
Background: Chronic hepatitis C is frequently associated with increased hepatic iron stores. It remains controversial whether heterozygous mutations of hemochromatosis genes affect fibrosis progression. Therefore our aim was to assess associations between HFE mutations and hepatic inflammation and …
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Genetische Assoziationsstudien der immunologisch relevanten Gene CCR5, CX3CR1 und RANTES zur klinischen Risikostratifizierung von Patienten mit chronischer Hepatitis C
Hepatitis C represents an inflammtion of the liver, which is influenced by a variety of epidemological and viral factors, as well as genetical traits of the host. This study examined the influence and impact of genetical variations of chemokine receptors such as CCR 5 and CX3CR1 and the chemokine …
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A study of immune responses during antiviral treatment for hepatitis C virus infection
Hepatitis C virus (HCV) is an RNA virus that primarily infects the liver, affecting 70 million people worldwide, according to new estimates (Polaris Observatory HCV Collaborators., 2017). Only 15-25% of persons infected with HCV will spontaneously clear the infection with the remaining developing …
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Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma.
… role and if it is expressed in the pre-cancerous hepatitis C virus (HCV) infected liver. In this thesis we show that OPN is expressed in the liver and in HCC as three variants, the full-length protein OPN-A and two splice variants OPN-B and OPN-C. Through production of stable Huh-7 cells …
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T-cell Dysfunction by HCV Core Protein Involves PD-1/PD-L1 Signaling.
<p>In 1989 the hepatitis C virus was identified as a significant cause of post-transfusion hepatitis. Nearly two decades later there is still no vaccine, inadequate treatment options, and limited understanding of how the virus establishes chronicity in the majority of the people it infects. Recent …
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Prävalenz und klinische Bedeutung von organspezifischen und nicht-organspezifischen Autoantikörpern bei Patienten mit Hepatitis-C-Infektion
… clearance in response to combination therapy for chronic hepatitis C infection. Therefore, despite of an overall higher treatment response, the addition of the immunomodulatory drug ribavirin could accentuate immunological differences that affect treatment outcome and might have been obscured in …
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Assoziation zwischen vier Polymorphismen des menschlichen Transforming-Growth-Factor-beta1-Gens und der zeitlichen Progression der posthepatitischen Leberfibrose
… with hepatic fibrosis (26 with known duration of hepatitis C virus infection), 47 patients with non-fibrotic diseases and 50 healthy blood donors, were analyzed for TGF-beta1 polymorphisms using ARMS-PCR and sequence analysis. The concentrations of total TGF-beta1 in plasma and of hyaluronan, …
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Characterizing B Cell Phenotype During Chronic HCV Infection
Chronic hepatitis C virus (HCV) infection is characterized by an attenuation of virus-specific T cell responses. The mechanisms leading to T cell attenuation are still not well understood, and likely involve several integrating correlates. We hypothesized that dysfunctions of antigen presenting …
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Avaliação do desempenho do índice APRI no diagnóstico de fibrose hepática em pacientes com Hepatite C crônica: uma revisão sistemática
… com “liver fibrosis” ou “liver fibroses” com “chronic hepatitis C” ou “hepatitis C, chronic”. Foram utilizados os filtros “Clinical Trial” e “Human”, e foram selecionados artigos em português, inglês ou espanhol. Resultados: Foram identificadas 292 publicações inicialmente, além de mais 8 …
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'It's All Very Blurry' : Exploring the Messy Realities of Living with Hepatitis C.
Across the UK, 200,000 - 500,000 people live with chronic hepatitis C. Spread through blood to blood contact, the main route of transmission in the UK is via sharing injecting drug use equipment. The negative perceptions which accompany this, coupled with the hidden nature of the illness and the …
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Cognitive, biological and psychosocial factors predicting interferon-alpha-induced depression
Interferon-alpha (IFN-α) therapy for chronic hepatitis C virus (HCV) infection is associated with the development of depression and other neuropsychiatric adverse effects. However, well-defined predictors of this depression are still lacking. Several interlinked biological systems as well as …
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