Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 701 for “"chromosomes"”.
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Polymer models of chromosomes
Studies of chromosomes have a long history. Since late XIX century, microscopy studies have revealed that chromosomal organization as seen by light microscopy is different among organisms, cell types, or stages of the cell cycle. However, the internal organization of chromosomes at scales below the …
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Mitotic Dynamics of Normally and Mis-attached Chromosomes and Post-mitotic Behavior of Missegregated Chromosomes
… was next used to study the metaphase dynamics of chromosomes with erroneous KT-MT attachments (Chapter 3). Once again, the model predictions were tested experimentally and showed that erroneous KT-MT attachment alters the dynamics not only of the mis-attached KT, but also of its sister KT. Even …
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Large-Scale Structure of Mitotic Chromosomes
… as forming the bases of DNA loops in metaphase chromosomes. To test the structural role of SAR/MAR sequences, we created stable cell lines containing chromosomes with regions of high density of integrated SAR/MAR sequences. CHO cells were isolated containing multiple copies of a vector …
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Reconstructing Chromothriptic Chromosomes in Oesophageal Adenocarcinomas
… and presence of structural variants. The chromosomes are then assembled separately and scaffolded using Hi-C reads, which we also haplotype resolve. This produces contiguous assemblies, even on chromosomes with over 900 structural rearrangements compared to the reference genome. This …
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Sequence of the chicken sex chromosomes
… occurring on the sex-specific W and Y chromosomes. In contrast, Z and X chromosomes are assumed to have diverged little from their autosomal progenitors. The Z and W sex chromosomes of the chicken provide a unique opportunity to study the evolution of sex chromosomes in a second lineage …
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Genetic Algorithms, Orthogonal Arrays and Diploid Chromosomes
… orthogonal array contributions a novel diploid chromosomes genetic algorithm that searches for robust optima was developed. Tests showed that it found the required optimum 100% of the time. A set of new measurement techniques suitable for presenting the results of the experiments performed and …
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Fusarium poae: Secondary Metabolism and Accessory Chromosomes
… architecture revealed the species harbors small chromosomes with structural features and genetic content consistent with rapidly evolving 'accessory' genomes in plant pathogenic fungi. Termed 'supernumerary' or 'accessory' chromosomes, these dynamic chromosomes can encode transcriptionally active …
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Characterization of the sex chromosomes in spinach
Plant sex chromosomes have evolved from the autosomes of hermaphroditic species to maintain dioecy. The major barriers to sex chromosome characterization have been the inherent difficulties of working with a non-recombining sex determining region that make sequencing and mapping the Male-Specific …
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Inference of 3D structure of diploid chromosomes
The spatial organization of DNA in the cell nucleus plays an important role for gene regulation, DNA replication, and genomic integrity. Through the development of chromosome capture experiments (such as 3C, 4C, Hi-C) it is now possible to obtain the contact frequencies of the DNA at the …
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Human chromosomes: structure, abnormalities and birth defects
… that revolve around the structure of human chromosomes and their relationship to birth defects. A new technique is described to produce spiralization of human metaphase chromosomes. The important feature is heat followed by trypsin treatment. By varying conditions, it is possible to produce …
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Organization of Human Sperm Chromosomes During Pronuclei Formation
… Recent studies have demonstrated that chromosomes of human spermatozoa have well-defined spatial organization that includes preferred intranuclear positioning. The hypothesis of this dissertation is that sperm chromosome architecture participates in controlled transformation and …
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Electron microscopic studies of mitotic chromosomes in yeast
… in yeast cell biology is whether or not the chromosomes of the yeast, Saccharomyces cerevisiae, condense during mitosis and, if they do, to what extent they are condensed.
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Dynamic organization of chromosomes in the mammalian cell nucleus
Uncovering the motifs of a higher order nuclear architecture and its implications on nuclear function has raised increasing interest in the past decade. The nucleus of higher eukaryotes is considered to display a highly dynamic interaction of DNA and protein factors. There is an emerging view that …
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Chromosomes and spermatozoa of the great apes and man
… rearrangements in the phylogeny of the chromosomes of man and the great apes, might not necessarily be restricted by infertility barriers, but may spread successfully in the population. The patterns of late replication of the chromosomes of the great apes and man have been compared, …
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Modeling Multi-fork Replication and Segregation of Bacterial Chromosomes
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-08-01
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Resolution of sex chromosomes in waterhemp and Palmer amaranth
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-08-01
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New methods in genetic search with real-valued chromosomes
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1996.
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