Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"chromosome mis-segregation"”.
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The effect of spindle geometry on the establishment of merotelic kinetochore attachment and chromosome mis-segregation
… in the human body. To accurately segregate chromosomes, the cell forms the bipolar mitotic spindle, a molecular machine that distributes chromosomes equally to the daughter cells. To this end, microtubules of the mitotic spindle must appropriately attach the kinetochores: protein structures …
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The effects of chromosome number changes on mitotic fidelity and karyotype stability
The correct number of chromosomes is important for the maintenance of healthy cells and organisms. Maintenance of a correct chromosome number depends on the accurate distribution of chromosomes to the daughter cells during cell division, and errors in chromosome segregation result in abnormal …
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Insights into the consequences of chromosome gains and losses in S. cerevisiae
… two identical daughter cells with faithful transmission of the genomic content. Errors in chromosome segregation lead to aneuploidy, a state of chromosomal imbalance where the karyotype is not an exact multiple of the haploid complement. At an organismal level, aneuploidy is the leading cause of …
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THE AUTOPHAGIC RECEPTOR P62 MODULATES MICRONUCLEUS STABILITY
… are extranuclear bodies originated because of chromosome mis-segregation. In the past years, several studies identified the processes that are dysfunctional in micronuclei and described the structures that are disrupted within them, revealing how micronuclei differ from primary nuclei. …
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MOLECULAR MECHANISMS ORCHESTRATING LYSOSOME-MEDIATED DEGRADATION OF RIBOSOMES IN ANEUPLOID CELLS
Chromosome segregation errors lead to the generation of aneuploid daughter cells with unbalanced karyotypes. This condition has a profound impact on cell physiology, causing a plethora of cellular stresses. One of the most prominent effects of abnormal karyotypes is the development of proteotoxic …
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Changes in Kinetochore Structure and Molecular Composition in Response to Mis-attachment
Each mitotic chromosome is constituted by two sister chromatids whose correct segregation to the daughter cells is ensured by amphitelic attachment, in which the two sister kinetochores (KTs) are attached to microtubules (MTs) from opposite mitotic spindle poles. KT mis-attachments can occur in …
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Mechanical Confinement and Heat as Drivers of Aneuploidy in Cancer
Aneuploidy, defined as an abnormal number of chromosomes, is a hallmark of human cancers and contributes to tumor evolution, heterogeneity, and therapeutic resistance. While classically attributed to chromosome mis-segregation during mitosis, emerging evidence indicates that diverse physical and …
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Post-Replicative Resolution of Under-Replication
… the confirmation of this relation by quantifying chromosome mis-segregation and DNA damage responses when origin number was reduced using RNAi against licensing factors. The number of ultrafine anaphase bridges and 53BP1 nuclear bodies are in remarkable concordance with the theoretical predictions …
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The dual use of cohesin and its protector Sgo1 contributes to the choreography of the chromosome and the centrosome cycle
Supernumerous centrosomes cause chromosome mis-segregation and genomic instability, thereby likely contributing to the development of cancer. Centrosome duplication in S phase requires the preceding licensing step in late mitosis/early G1 phase, centriole disengagement. Reminiscent of the control …
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Analysis of the S. pombe sister chromatid cohesin subunit in response to DNA damage agents during mitosis.
… has proved invaluable in modern medicine. Chromosomes can be perceived as the packages for genetic information; they are replicated during S phase in both mitosis and meiosis to produce two identical sister chromatids which are subsequently segregated during the respective anaphases of both …