Global ETD Search
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Showing 1 to 2 of 2 for “"chromosome end protection"”.
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Defining Multiple Steps in Human Telomere End Processing
Telomere overhangs are essential for chromosome end protection and telomerase extension, but how telomere overhangs are generated is unknown. Due to the classic end replication problem, leading DNA daughter strands are initially blunt while lagging daughters are shorter by at least the size of the …
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Mechanisms of Telomere End Protection by TRF2
… a six-subunit protein complex that protects the ends of mammalian chromosomes, called telomeres. The six subunits of shelterin, TRF1, TRF2, TIN2, TPP1, POT1, and Rap1, each have distinct roles in telomere homeostasis. These include telomere length regulation and preventing telomeres from …