Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"chromosome architecture"”.
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Genetic and biochemical interactions between the DNA replication initiator and a chromosome architecture protein in Bacillus subtilis
I described the co-association, in vitro interaction, and epistatic relationship between the DNA replication initiator DnaA and the nucleoid-associated protein Rok in Bacillus subtilis. Using ChIP-seq, I characterized the genome-wide association of DnaA and its regulator YabA. I found that DnaA and …
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A role for the Bacillus subtilis Structural Maintenance of Chromosomes (BsSMC) protein in chromosome organization and compaction
All cells must compact their chromosomes in order for the DNA to fit inside the cell or nucleus. In Bacillus subtilis, and other bacteria, replication occurs simultaneously with the organization, compaction and segregation of newly duplicated chromosomal regions. My work indicates that the B. …
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Genome-Wide and Multi-Scale Mapping of DNA Supercoiling in Differentiating Human Stem Cells
… were shown to impact gene expression and chromosome architecture. Nonetheless, its intrinsic dynamic and multifaceted nature, together with experimental limitations, have hindered the study of the timing and factors orchestrating supercoiling formation and dissolution across human …
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Investigation of replication fork progression and re-replication fork instability at the Drosophila follicle cell amplicons
… is influenced by sequence, chromatin and/or chromosome architecture. Additionally, we have developed a slope analysis tool to measure changes in fork progression between different amplicons, as well as within a single amplified site. Together the CGH survey and slope analysis can be used to …
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Organization of Human Sperm Chromosomes During Pronuclei Formation
<p>Chromosome organization is regarded as an important factor in regulating gene expression. In addition to the histone code, it is a part of the epigenetic mechanisms participating in fertilization and early embryonic development. Recent studies have demonstrated that chromosomes of human …
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STUDIES IN OOCYTES FROM THREE MAMMALIAN SPECIES DEMONSTRATE THAT MEIOTIC KINETOCHORES ARE COMPOSED OF PREVIOUSLY UNIDENTIFIED SUBDOMAINS AND REVEAL TWO NOVEL MECHANISMS BEHIND THE MATERNAL-AGE EFFECT IN HUMANS
… women frequently contain an incorrect number of chromosomes and are therefore unlikely to give rise to a viable pregnancy, the incidence of chromosomally abnormal eggs increases strikingly with advancing maternal age. Why egg quality declines dramatically as women approach their forties remains …
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A genetic interaction network of constitutive heterochromatin in Caenorhabditis elegans
… genomes that is important for gene regulation, chromosome architecture and the maintenance of genome integrity. It is associated with the silencing of gene expression and the repression of repetitive element activity. Constitutive heterochromatin is also an important modulator of development and …
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Higher Order Chromosome Organization and Recombination Dynamics of Meiotic Prophase I In Mouse Spermatocytes
<p>Meiotic recombination is required for parental chromosomes to find each other (pairing/synapsis) and to exchange genetic information thus allowing faithful segregation of chromosomes and the production of haploid gametes. At the start of meiotic prophase I, meiotic chromosomes organize into loop …
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Functional investigation of the role of the retinoblastoma protein in genome stability
… promoters is required to establish long-range chromosome interactions and transcriptional insulation between gene pairs. In addition, pRB deletion in cancer causes similar misregulation at divergent promoters, indicating that loss of insulation impacts the transcriptome of cancer cells. …