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Showing 1 to 18 of 18 for “"chromosome aberrations"”.

  1. Chromosome aberrations in field strains of Blattella germanica

    Crouch, Joelle H.Virginia Tech1993

    … the German cockroach were compared for possible chromosome aberrations. Resistant strain females produced significantly higher numbers of aberrant oothecae ( >5 unhatched eggs ) than the susceptible strains. Chromosome aberrations found in the susceptible strains were attachments …

    vt Repository record

  2. Fast Monte Carlo Cell-By-Cell Simulation of Radiation-Induced DNA Damage, Chromosome Aberrations, and Cell Death for Low-Dose-Rate Brachytherapy Sources

    Dick, Joseph S.Georgia Institute of Technology2025

    … of radiation damage to DNA and the resulting chromosome aberrations has enabled studies of cell survival characteristics to be performed via computer simulation. TOPAS, a Monte Carlo based physics modeling tool, contains models of the brachytherapy sources commonly used in radiation therapy …

    gatech Repository record

  3. In-vivo investigation of resveratrol as a preventive for radiation-induced acute myeloid leukemia

    Carsten, Ronald E., author, Ullrich, Robert L., advisorColorado State University. Libraries2008

    … ability to reduce radiation-induced chromosome aberrations and PU.1 gene loss in mouse bone marrow cells. Loss of 1 PU.1 gene and missense mutation of the remaining allele leads to acute myeloid leukemia in CBA mice.

    colostate Repository record

  4. The structure and evolution of breast cancer genomes

    Newman, ScottUniversity of Cambridge2011

    Chromosome changes in the haematological malignancies, lymphomas and sarcomas are known to be important events in the evolution of these tumours as they can, for example, form fusion oncogenes or disrupt tumour suppressor genes. The recently described recurrent fusion genes in prostate and lung …

    cambridge Repository record

  5. Biological and Functional Consequences of Single Nucleotide Polymorphisms of the O6-Methylguanine-DNA-Methyltransferase Gene

    Cross, Courtney 1981-The University of Texas Medical Branch at Galveston2016

    … between genetic damage and SNPs in MGMT; chromosome aberrations to examine macrolesions, and mutation frequency to examine microlesions. In addition, we used the luciferase reporter assay to determine effects of SNPs in the promoter/enhancer region of MGMT on promoter activity. Coding SNPs …

    utmb Repository record

  6. Radiation-induced bystander fibroblasts both reduce and amplify micronuclei induction through the reciprocal bystander effect and the secondary bystander effect

    Liu, ChangMassachusetts Institute of Technology2016

    … assay was used to analyze the amount of chromosome aberrations present. In the unirradiated secondary bystander population, an increase in percentage of binucleated cells with micronuclei from the background level to approximately the level of the primary bystander cells was observed, …

    mit Repository record

  7. Inactivation synergy between high energy neutrons and ⁶⁰Co gamma rays

    Slabbert, Jacobus PetrusDivision of Radiology1993

    … delay measurements and micronuclear formations. Chromosome aberrations showed synergy between neutron and photon damage in human lymphocytes, as predicted by interaction functi ons. However, the synergistic interaction noted with micronuclear formation in binucleate cells was at variance with …

    cape-town Repository record

  8. Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems

    McEllin, Brian Matthew2012

    … as astrocytes show increased radial chromosome aberrations and decreased sister chromatid exchanges after PTEN loss. These results have exciting implications, as it has identified two potential new therapeutic strategies for improving treatment in subsets of GBM patients. The cancer …

    utswmed Repository record

  9. Regulation of Rad51D In Homologous Recombination Dna Repair by Alternative Splicing and Ubiquitin Modification

    Yard, Brian David

    … to repair DNA damage as well as maintain chromosome and telomere stability. In the first study, mouse Rad51d alternative transcript products were found to make specific interactions with RAD51C and XRCC2. In addition, Rad51d alternative transcripts exhibited tissue-specific expression …

    south-carolina Repository record

  10. Detection of Aneuploidy for Chromosomes 7 and 8 Using Fluorescence <i>In Situ</i> Hybridization in Patients with Aplastic Anemia and Sequencing of the Mitotic Checkpoint Gene hBUB1

    Aridgides, Laura Jane2019

    … is the current method of choice to evaluate chromosome aberrations. However, fluorescence <em>in situ</em> hybridization (FISH) is more sensitive in detecting these abnormalities.</p> <p><em>hBUB1</em>, a mitotic spindle checkpoint gene, was shown to be mutated in two colorectal cancer cell …

    odu Repository record

  11. Driver genes associated to Broad Copy Number Aberrations in solid cancers

    PRIVITERA, ANNA PROVVIDENZA ESTERUniversità degli studi di Catania2022

    Large numerical and structural chromosomal aberrations (aneuploidy) are intrinsic features of tumour cells and cell transformation. The chromosomal aberrations are collectively called Broad Copy Number Aberrations (BCNAs) and mainly include aneuploidy (i.e. an incorrect number of one or more …

    catania Repository record

  12. Trisomies in Hematologic Malignancies

    Paulsson, KajsaSection of Clinical Genetics, Institution of Laboratory Medicine, Lund University Hospital2005

    Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.., …

    lund Repository record

  13. Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer

    Amadi, Emmanuel E.University of Bradford2019

    … (DNA damage) and cytogenetic effects (chromosome aberration parameters) induced by GO NMs on human whole blood from healthy individuals and patients were studied using the Alkaline Comet Assay and Cytokinesis-blocked Micronucleus (CBMN) assay, respectively. Our results showed …

    bradford Repository record

  14. Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer

    Amadi, Emmanuel E.University of Bradford2019

    … (DNA damage) and cytogenetic effects (chromosome aberration parameters) induced by GO NMs on human whole blood from healthy individuals and patients were studied using the Alkaline Comet Assay and Cytokinesis-blocked Micronucleus (CBMN) assay, respectively. Our results showed …

    bradford Repository record

  15. Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics

    Tšuiko, Olga2018

    tartu

  16. Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation

    Bakhmutsky, Marina Victoria2013

    … function of uranium (U) body burden by measuring chromosome damage in peripheral blood lymphocytes with the cytokinesis blocked micronucleus assay (CBMN) and fluorescence in situ hybridization (FISH) whole chromosome painting. Study subjects are Gulf War I Veterans exposed to DU during friendly …

    wayne-thes Repository record

  17. ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΩΝ ΕΠΙΔΙΟΡΘΩΤΙΚΩΝ ΜΗΧΑΝΙΣΜΩΝ ΤΟΥ DNA ΣΕ ΛΕΜΦΟΚΥΤΤΑΡΑ ΑΤΟΜΩΝ ΜΕ ΣΥΝΔΡΟΜΟ DOWN

    Athanasiou, Kyriacos, Αθανασίου, ΚυριάκοςUniversity of Patras1981

    THE CAPABILITY OF CELLS FROM CHILDREN WITH DOWN'S SYNDROME TO REPAIR X-RAY INDUCED DAMAGE IN DNA WAS STUDIED BY MEANS OF THREE DIFFERENT METHODS, NAMELY: 1) BY COUNTING SISTER CHROMATID EXCHANGES (SCE) IN NORMAL AND DOWN CELLS WHICH WEREFOUND OF SIMILAR LEVELS. IN THIS RESPECT DS RESEMBLES …

    greece Repository record

  18. Wirkung schwerer Ionen auf strahlenresistente und strahlensensitive Tumorzellen

    Hofman-Hüther, Hana2012

    … auch die Induktion von strukturellen Chromosomenaberrationen nach Bestrahlung mit Kohlenstoffionen verschiedener Energien (100 MeV/u, 200 MeV/u, 400 MeV/u und im ausgedehnten Bragg Peak) im Vergleich zur 200 kV-Röntgenstrahlung untersucht. Zusätzlich wurden auch die an der …

    goettingen Repository record