Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"chromosome aberration"”.
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The structure and evolution of breast cancer genomes
Chromosome changes in the haematological malignancies, lymphomas and sarcomas are known to be important events in the evolution of these tumours as they can, for example, form fusion oncogenes or disrupt tumour suppressor genes. The recently described recurrent fusion genes in prostate and lung …
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Evaluation of 64Cu-ATSM in cell culture for potential use as a radiotherapy agent
… the effective LET of 64Cu-ATSM. Additionally, chromosome aberration and H2AX DNA double strand break (DSB) studies were performed to examine DNA damage from 64Cu-ATSM. 64Cu-ATSM was also administered to multiple additional cell lines under various -oxic states to evaluate how efficiently …
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Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer
… (DNA damage) and cytogenetic effects (chromosome aberration parameters) induced by GO NMs on human whole blood from healthy individuals and patients were studied using the Alkaline Comet Assay and Cytokinesis-blocked Micronucleus (CBMN) assay, respectively. Our results showed …
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Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer
… (DNA damage) and cytogenetic effects (chromosome aberration parameters) induced by GO NMs on human whole blood from healthy individuals and patients were studied using the Alkaline Comet Assay and Cytokinesis-blocked Micronucleus (CBMN) assay, respectively. Our results showed …
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Characterization of chromosomal abnormalities in acute myeloid leukaemia patients at the university teaching hospital, Lusaka, Zambia
… most patients with AML harbour at least 1 chromosome aberration in their marrow blasts. With the targeted cytogenetic therapy, 30% of the patients achieve long-term cure. At University Teaching Hospital(UTH) however, the current diagnostic approach of acute leukaemia involves mainly …
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Characterization of chromosomal abnormalities in acute myeloid leukaemia patients at the university teaching hospital, Lusaka, Zambia
… most patients with AML harbour at least 1 chromosome aberration in their marrow blasts. With the targeted cytogenetic therapy, 30% of the patients achieve long-term cure. At University Teaching Hospital(UTH) however, the current diagnostic approach of acute leukaemia involves mainly …
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Biological and Functional Consequences of Single Nucleotide Polymorphisms of the O6-Methylguanine-DNA-Methyltransferase Gene
… between genetic damage and SNPs in MGMT; chromosome aberrations to examine macrolesions, and mutation frequency to examine microlesions. In addition, we used the luciferase reporter assay to determine effects of SNPs in the promoter/enhancer region of MGMT on promoter activity. Coding SNPs …
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Driver genes associated to Broad Copy Number Aberrations in solid cancers
Large numerical and structural chromosomal aberrations (aneuploidy) are intrinsic features of tumour cells and cell transformation. The chromosomal aberrations are collectively called Broad Copy Number Aberrations (BCNAs) and mainly include aneuploidy (i.e. an incorrect number of one or more …
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Trisomies in Hematologic Malignancies
Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.., …
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Vergleich von Mikronukleus- und Chromosomenaberrationstechnik bei der Dokumentation zytogenetischer Schäden in neoadjuvant radio-chemotherapierten Rektumkarzinompatienten
… Der Mikronukleustest, ebenso wie die Analyse von Chromosomenaberrationen sind zuverlässige Methoden zur Darstellung von Schäden des Zellgenoms in vivo und in vitro. Es wurden Ergebnisse und Durchführbarkeit beider Methoden untersucht und diese in Bezug auf die Beurteilung der zytogenetischen …
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Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia
… and principal component analyses of BAC array chromosome-wide methylome profiles accurately subgrouped the t(12;21) and HeH ALL subtypes, demonstrating that they are characterized by subtype specific methylomes. Analysis of promoter-specific CpG islands demonstrated that several B-cell- and …