Global ETD Search
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Showing 1 to 10 of 10 for “"chromosomal passenger complex"”.
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Regulation of Chromosome Segregation by the Chromosomal Passenger Complex
… understood. Here I describe the role of the chromosomal passenger complex (CPC) in the regulation of chromosome segregation, using Xenopus egg extracts. The CPC contains the kinase Aurora B, which is well known for its phosphorylation of serine 10 on histone H3 (H3S10). While this …
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Regulated Recruitment of the Chromosomal Passenger Complex to Chromatin and Microtubules Promotes Accurate Cell Division
<p>Aurora B, the kinase subunit of the chromosomal passenger complex (CPC), promotes accurate cell division by destabilizing erroneous kinetochoremicrotubule attachments and activating the spindle assembly checkpoint (SAC). Both functions require Aurora B activation, which is promoted by its …
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The role of the chromosomal passenger complex and condensin complex in meiotic chromosome cohesion and segregation
… molecularly characterized as an allele of the passenger complex component incenp.
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Control of Chromosome Segregation by the Aurora B Complex
… the composition and function of the vertebrate chromosomal passenger complex (CPC), known to include Incenp, Survivin, and the kinase Aurora B. We report the identification of Dasra A and Dasra B as two new components of the vertebrate CPC, and demonstrate that the CPC is required for …
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Examining Intracellular Phosphorylation Gradients During Cell Division
… a phosphorylation gradient for substrates of the chromosomal passenger complex (CPC). CPC is a conserved regulator involved in key mitotic events such as chromosome-microtubule attachment and spindle midzone formation. Previously, spatial phosphorylation gradients have been reported for CPC …
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RNA localizations of proteins that interact with the chromosome passenger complex
… towards a comprehensive understanding of how the chromosomal passenger complex affects ncRNA transcripts throughout mitosis, and how the complex plays a role in retention of silencing in daughter cells by governing mitotic dispersal of ncRNA. We demonstrated ncRNA dispersal is needed for …
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The regulation of chromosome segregation by Aurora kinase, protein phosphatase 1 and nucleolar protein UTp7
The Sli15-Ipl1-Bir1 chromosomal passenger complex is essential for proper kinetochore-microtubule attachment and spindle stability in the budding yeast Saccharomyces cerevisiae. Subcellular localization of this complex during anaphase is regulated by the Cdc14 protein phosphatase, which is kept …
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Structural and Mechanistic insights into Centromere Specification and Kinetochore Regulation
… onto which the kinetochore assembles and 2) the chromosomal passenger complex (CPC) which regulates kinetochore-microtubule interactions to ensure accurate genome partitioning between cells. In the first part of this work, we used a combination of in vitro, genomic sequencing, and novel …
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Mechanistic Insights into the Microtubule-Mediated Differential Modulations of Aurora B Substrate Structures for Accurate Chromosome Segregation
… regulated by Aurora B, the kinase subunit of the Chromosomal Passenger Complex (CPC). How Aurora B can distinguish between erroneous and correct attachments and selectively phosphorylate its key substrates in the right contexts remains poorly understood. The Ndc80 complex (Ndc80C) is a key …
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Mitotic slippage by ATP depletion and its mechanism
… that activity of Haspin to recruit the chromosomal passenger complex (CPC) at centromeres is also attenuated during mitotic slippage. Overall, inactivation of Aurora B and Haspin at centromeres by ATP depletion contributes to the induction of mitotic slippage. We also observed the …