Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"chromosomal instability (CIN)"”.
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Telomeric Regulation of Chromosomal Instability In Colorectal Cancer
<p>Telomere dysfunction drives chromosomal instability (CIN) during the transition from benign adenoma to malignant adenocarcinoma. While CIN provides a mutator mechanism for cancer-relevant genomic events, its role in shaping tumor biology during carcinogenesis is not well understood. Here, we …
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Chromosomal instability and tumorigenesis : genetic analysis of the murine spindle checkpoint gene Mps1
… of the mammalian spindle checkpoint can cause chromosomal instability (CIN), the frequent gain or loss of entire chromosomes during cell divisions. While CIN has been proposed to be sufficient to initiate tumorigenesis, no direct evidence has shown that CIN itself is a causal agent for human …
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Revealing the Mechanisms of Tumorigenesis Through Multi-Omics Analyses
… and external influences such as environmental carcinogens and oncogenic pathogens. This heterogeneity, coupled with genomic evolution and multilayered crosstalk within tumor ecosystems, highlighted the complexity of cancer. The advancement of high-throughput sequencing technologies has …
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Graph Representation Learning to Study the Tumour Microenvironment
… TME patterns and different definitions of chromosomal instability (CIN). The results indicate that a combination of immune cells and markers associated with breast cancer, as well as cellular birth and death processes, play significant roles in different CIN metrics. These results support …
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Novel genomic technologies and molecular diagnostics in Colorectal Cancer
… according to the presence of microsatellite instability (MSI) and chromosomal instability (CIN). Of the 51 CRCs, 13.73% were MSI and 86.27% were microsatellite stable (MSS). The frequency of KRAS mutations in MSI-H and in MSS cancer was 28.57% and 40.91%, respectively. To identify and …
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Role of Amplification of Chromosome 6P12-P21 in Human Osteosarcoma
… arises as a result of unusually high levels of chromosomal instability (CIN), which causes numerous copy number changes. This extensive CIN leads to genomic gains or amplifications of various chromosomal regions including, frequently, a portion of chromosome 6 between cytobands 6p12-p21. The …
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INFERRING TUMOR PROPERTIES FROM GENE EXPRESSION DATA
… have been shown to exist for mutation load and chromosomal instability (CIN). We wonder whether a similarly non-monotonic relationship occurs also at gene expression level and demonstrate that for some genes a poor or favorable outcome is found at a medium transcription level and that the shape …
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Defining the role(s) of non-classical tumour suppressor Wwox in cellular function using Drosophila melanogaster genetic modelling
… as the gene that spans the FRA16D common chromosomal fragile site (CFS), which is a frequent site of DNA instability in cancer. Perturbation of the WWOX gene has been reported in various cancers, with low WWOX levels correlating with poorer prognosis. Individuals who inherit a …
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Signatures of chromosomal instability in human cancers
Chromosomal instability (CIN), defined as the process of losing or gaining whole or parts of chromosomes, is one of the earliest molecular characteristics to be described in cancer. Since its detection by light microscopy in the late 19th century, technological advances have facilitated the …
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The effect of spindle geometry on the establishment of merotelic kinetochore attachment and chromosome mis-segregation
… chromosomes at high rates, a phenotype termed chromosomal instability (CIN). CIN has been correlated with both advanced tumorigenesis and poor patient prognosis and over the years there have been many hypotheses for what causes CIN. In this study, we identified two distinct mechanisms that are …
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Constitutively active-RSK2 induces chromosomal instability through diverse mechanisms
… loss and/or gain of single chromosomes through chromosomal instability may be the most common pathway to aneuploidy. We observed that constitutively acvtive RSK2 induced chromosomal instability such as lagging chromosome and chromosome bridge, micro-nucleus and abnormal number of chromosome. …
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Modeling Sporadic Tumor Formation Driven By Telomere Dysfunction In The Gastrointestinal Tract
… in sporadic colon cancer; one of which is chromosomal instability (CIN). One hypothesized driver of CIN in cancer is the improper repair of dysfunctional telomeres. Telomeres comprise the linear ends of chromosomes and play a dual role in cancer. Its length is maintained by the …
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Biomarkers of Genome Instability and Disease Progression in Ovarian Cancer
High grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer and the major cause of gynaecological cancer-related deaths in the Western world. Overall survival for HGSOC patients has not improved over the last two decades, and the progressive evolution of chemotherapy …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… by specific hallmarks of cancer, including chromosomal instability (CIN), epithelial-to-mesenchymal transition (EMT), and cancer-related immune responses. In particular, the tumour immune microenvironment and the interaction between immune and cancer cells are emerging as crucial factors in …
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Targeting chromosomal instability: screening and characterization of CIN killers.
Chromosomal INstability (CIN), a hallmark of cancer cells, refers to a state in which cells have an increased rate of gain or loss of whole chromosomes or large chromosomal fractions. CIN is linked to the progression of tumours with poor clinical outcomes such as drug resistance and metastasis. …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… genica nel cancro, concentrandosi sul carcinoma colorettale e sull'adenocarcinoma mammario. Studi precedenti hanno esaminato come le aberrazioni cromosomiche di tipo “gain” (guadagno), in particolare nei cromosomi 20, 8q, 13 e 7, influenzino le regioni codificanti nel carcinoma colorettale …