Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"chromosomal breakage"”.
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Human common fragile sites, identification, and analysis of breaks using <i>saccharomyces cerevisiae</i>
… leading to replication fork stalling and chromosomal breakage, and (2) Fragile site regions lack sufficient origins of replication, which paired with replication stress results in failure to complete replication before mitosis and eventual breakage of unreplicated DNA. To test these …
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RAD51-MEDIATED ABASIC SITES PROTECTION PREVENTS REPLICATION FORK COLLAPSE.
… are repaired within ssDNA to avoid catastrophic chromosomal breakage remain unclear. Genes encoding for some BER proteins are synthetically lethal with BRCA1/2, which are frequently mutated in several type of cancers, including ovarian and breast cancer. In this study, we utilized the Xenopus …
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Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes.
… with MYCN amplification and the generation of chromosomal breakage-fusion bridge cycles and could confirm that MYCN amplification was associated with reduced tumour telomere length in vivo. We also found a possible association between poor survival and elongated telomeres, which needs to be …
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Einfluß von Alter und Genotyp auf die Zellzyklusverteilung mononukleärer Zellen des peripheren Blutes nach Kurzzeitkultur und bivariater Durchflußzytometrie
Anhand konsekutiver Zellzyklen wird das Proliferationsmuster PHA-stimulierter Lymphozyten bei Fanconi Anämie (FA), Ataxia teleangiectasia (AT), AT-verwandter Syndrome und Aplastischer Anämie untersucht und die Zellzyklusdaten als Funktion von Probandenalter und klinischer Diagnose dargestellt. Die …