Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"chromosomal aberration"”.
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Variation in chromosomal aberration induction in differing ATM and ASPM genotypic backgrounds detected via a modified PNA FISH technique
… quantitative and qualitative analysis of chromosomal aberration formation. PNA FISH was used to detect a heightened sensitivity in mouse fibroblasts in response to ionizing radiation with Atm-/- and in mouse embryonic fibroblasts (MEFs) in response to loss of Aspm gene respectively. For …
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An investigation into the potential mutagenicity of South African traditional medicinal plants
… and clastogenicity (ability to cause chromosomal damage) of five South African traditional medicinal plants: Acokanthera oppositifolia (Lam.); Pelargonium sp. cf. inquinans ( L.) L Herit; Pteridium aquilinum subsp aquilinum; Rumex lanceolatus Thunb. and Zantedeschia aethiopica (L.) Sg, …
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Human embryonic stem cells for genotoxicity testing
… as a cellular model for genotoxicity testing. Chromosomal analysis by PNA-FISH and mFISH following Mitomycin C treatment revealed that hESCs are significantly more resistant to genotoxic damage than normal human fibroblast cell line as evidenced by the lower levels of chromosomal aberration in …
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Epigenetic Determinants of CRISPR-Cas9 genotoxicity
… and the likelihood of off-target effects or chromosomal rearrangements. However, these events are rare enough to be beyond the sensitivity of standard sequencing technologies, so their identification requires bespoke approaches. To assess genotoxicity linked to Cas9-mediated genome editing, …
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The genetic causes of mental retardation in Estonia: fragile X syndrome and creatine transporter defect
… finding in cases of rare submicroscopic chromosomal aberration, which causes MR in complicated dysmorphic patients. In this study, two patients with submicroscopic copy number variation in chromosomes X and 17q were being described. Uuringus analüüsitakse kahte sagedasemat X-liitelise …
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Characterization of chromosomal abnormalities in acute myeloid leukaemia patients at the university teaching hospital, Lusaka, Zambia
… patients with AML harbour at least 1 chromosome aberration in their marrow blasts. With the targeted cytogenetic therapy, 30% of the patients achieve long-term cure. At University Teaching Hospital(UTH) however, the current diagnostic approach of acute leukaemia involves mainly cytomorphology and …
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Characterization of chromosomal abnormalities in acute myeloid leukaemia patients at the university teaching hospital, Lusaka, Zambia
… patients with AML harbour at least 1 chromosome aberration in their marrow blasts. With the targeted cytogenetic therapy, 30% of the patients achieve long-term cure. At University Teaching Hospital(UTH) however, the current diagnostic approach of acute leukaemia involves mainly cytomorphology and …
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Exposure, telomere length, and cancer risk
… the association between telomere length and chromosomal aberrations in blood, a biomarker for cancer risk. Different study populations were recruited to elucidate specific hypothesises: In the first study 157 workers in rubber industry were recruited to investigate the effect of exposure to …
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Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
… bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural chromosomal aberrations and was also associated with …