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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 756 for “"chromosomal"”.
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Chromosomal Evolution of Malaria Vectors
… are highly plastic as evidenced by the wealth or chromosomal inversions that have occurred in this genus. Chromosomal inversions have been correlated with differences in adaptation to aridity, insecticide resistance, and differences in resting behavior. However, a good understanding of the …
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Mechanisms of Palindrome-Mediated Chromosomal Instability
… are highly unstable DNA sequences that induce chromosomal rearrangements and underlie cancer and hereditary diseases such as Emanuel Syndrome. Despite being a significant source of genomic instability, the mechanisms governing palindrome fragility in eukaryotic cells are not fully defined. In …
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Studies in GPCR and Chromosomal Control
This dissertation is divided into two distinct parts. The first chapter is focused on regulation of serotonin receptors and signaling to address drug addiction, while the second chapter is focused on a novel synthetic approach towards a small molecule inhibitor of Ewing’s sarcoma. Drug addiction is …
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Chromosomal proteins in activation of transcription
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Carboxyl Methylation of Non-Histone Chromosomal Proteins
<p>The <u>in vitro</u> methylation of non-histone chromosomal proteins (NHCP) was investigated in nuclei isolated from the brain, liver, and thymus of 6-8-day-old rats. After incubating the nuclei in the presence of 20 μM S-adenosyl-L-[methyl-<sup>3</sup>H]methionine(l Ci/mmol), the NHCP were …
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Chromosomal Evolution Among North American Microtine Rodents
Comparative chromosomal analyses among 21 species of New World and one species of Old World microtine rodents were carried out. Species belonged to eight different genera and included 14 species of Microtus. Three differential staining procedures were utilized: C-banding, G-banding, and silver …
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Chromosomal Control of Nucleolar Composition in Maize
Made available in DSpace on 2014-12-05T22:00:05Z (GMT). No. of bitstreams: 1 0010507.pdf: 2589068 bytes, checksum: 90232a9531e43bf3d1404a5c64763e39 (MD5) Previous issue date: 1954
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Signatures of chromosomal instability in human cancers
Chromosomal instability (CIN), defined as the process of losing or gaining whole or parts of chromosomes, is one of the earliest molecular characteristics to be described in cancer. Since its detection by light microscopy in the late 19th century, technological advances have facilitated the …
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Chromosomal evolution in mosquitoes - vectors of diseases
The World Health Organization estimates that vector-borne diseases account for 17% of the global burden of all infectious diseases and has identified the mosquito as the most dangerous of all disease-transmitting insects, being responsible for several million deaths and hundreds of millions of …
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Genomic Characterization of Recurrent Chromosomal Aberrations in Retinoblastoma
… mutational events, specifically gain and loss of chromosomal regions harbouring key oncogenes and tumour suppressor genes, appear to underlie the progression of precursor lesions such as retinoma to retinoblastoma. Research thus far has implicated several cytogenetic aberrations in this sequence …
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Telomeric Regulation of Chromosomal Instability In Colorectal Cancer
<p>Telomere dysfunction drives chromosomal instability (CIN) during the transition from benign adenoma to malignant adenocarcinoma. While CIN provides a mutator mechanism for cancer-relevant genomic events, its role in shaping tumor biology during carcinogenesis is not well understood. Here, we …
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Mitochondrial and chromosomal genomics in type 2 diabetes
Understanding the mechanisms of complex polygenic diseases like type 2 diabetes (T2D) is as complex as their nature. Cellular processes involved in glucose homeostasis need high and reliable energy supply. Mitochondria are the major energy producers in mammalian cells. Since majority of the …
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Molecular cytogenetics and genetic characterisation of chromosomal rearrangements
… technologies to investigate germline and somatic chromosomal rearrangements in humans. Firstly, 16 patients with cytogenetically detectable deletions of 3p25-p26 were analysed with high density single nucleotide polymorphism (SNP) microarrays; Affymetrix 250K SNP microarrays (n=14) and Affymetrix …
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Heterotic Effects of a Chromosomal Segment in Maize
Made available in DSpace on 2014-12-05T22:00:07Z (GMT). No. of bitstreams: 1 0023309.pdf: 3609967 bytes, checksum: 7a38c816fe0063ce7f18c8a1c1ef16df (MD5) Previous issue date: 1957
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A chromosomal analysis of 25-day pig embryos
… Hampshire boars to produce 25-day embryos for chromosomal analysis. Blood samples were drawn from five of these gilts and one of the boars for leucocyte cultures and a comparison was made between karyotypes prepared from the dam with those prepared from her 25-day embryos. The mean ovulation …
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Comparative genomics of chromosomal rearrangements in malaria mosquitoes
To better understand the evolutionary dynamics of chromosomal inversions, a physical map for an Asian malaria vector, Anopheles stephensi, was created and compared with the maps of the major African malaria vectors A. gambiae and A. funestus No interchromosomal transposition was observed between A. …
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