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Showing 1 to 20 of 114 for “"chromatin remodeling"”.

  1. STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE ISW2 CHROMATIN REMODELING COMPLEX

    Hota, Swetansu Kumar

    Chromatin remodelers utilize the energy derived from ATP hydrolysis to mobilize nucleosomes. ISWI remodelers mobilize and evenly space nucleosomes to regulate gene expression. ISW2, an ISWI remodeler in yeast, has been shown to reposition nucleosome near promoter regions and represses both mRNA and …

    siu-theses Repository record

  2. The Effects of Chromatin Remodeling and Pseudokinase Activity on Liver Pathophysiology

    Moore, Austin Bradley2023

    … Arid1a, a DNA-binding component of the SWI/SNF chromatin remodeling complex, shifts hepatocyte metabolism to promote lipid accumulation in a manner similar to that seen in non-alcoholic fatty liver disease. We further explore the dynamics of the SWI/SNF complex by examining a mutually exclusive …

    utswmed Repository record

  3. SWI/SNF COMPLEXES COORDINATE WITH HISTONE MODIFICATIONS TO REGULATE CHROMATIN REMODELING

    Chatterjee, Nilanjana

    SWI/SNF, the founding member of ATP dependent chromatin remodelers and its paralog RSC in yeast perform similar yet distinct functions inside the cell. In vitro these complexes use ATP dependent DNA translocation to either mobilize or disassemble nucleosomes. However, how these complexes interact …

    siu-theses Repository record

  4. The Role of Chromatin Remodeling in Hippocampus in Depression and Antidepressant Action

    Tsankova, Nadejda Mincheva2010

    … with antidepressants: regulation at the level of chromatin remodeling. The technique of brain chromatin immunoprecipitation was pioneered to directly measure the in vivo modifications of histones, a form of chromatin remodeling, at gene promoter regions in the hippocampus after chronic defeat …

    utswmed Repository record

  5. The Functional Roles for SWI/SNF Chromatin Remodeling Complexes in Physiology and Disease

    Celen, Cemre2023

    … haploinsufficiency of ARID1B, a SWI/SNF chromatin-remodeling subunit, has been implicated in short stature, autism spectrum disorder, intellectual disability, and corpus callosum agenesis. In addition, ARID1B is the most common cause of Coffin-Siris Syndrome, a developmental delay …

    utswmed Repository record

  6. The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling

    Andersen, Erik CMassachusetts Institute of Technology2008

    … presumptive transcriptional repressors and chromatin-remodeling factors. The synMuv genes likely repress the transcription of the Ras pathway ligand lin-3 EGF. Some class B synMuv proteins are homologs of a Nucleosome Remodeling and Deacetylase (NuRD)-like complex and heterochromatin protein …

    mit Repository record

  7. Psychosocial Distress Mediates Immune Dysregulation Through Alterations in Global Epigenetic Patterns and Chromatin Remodeling Proteins

    Krukowski, Karen1970

    … both an epigenetic modification (H4-K8-Ac) and a chromatin remodeling protein (HDAC2) as indicators of GC mediated immune dysregulation in NK cells of women experiencing psychosocial distress.</p>

    loyola-thes Repository record

  8. A functional role of chromatin remodeling factor, Rsf-1 in the DNA damage signaling pathway

    조, 수진2014

    … imitation switch (ISWI) family in ATP-dependent chromatin remodeling factors, RSF complex consists of SNF2h ATPase and Rsf-1. Although it has been reported that SNF2h ATPase is recruited to DNA damage sites (DSBs) in poly(ADP-ribosyl) polymerase 1 (PARP1)-dependent manner in DNA damage response …

    ajou Repository record

  9. LINKING CHROMATIN REMODELING TO MITOCHONDRIAL DYSFUNCTION: A ROLE FOR THE SMARCA5-MYC-TFAM AXIS IN HEPATOCELLULAR CARCINOMA

    PALERMO, FRANCESCAUniversità degli Studi di Milano2025

    … Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 5), an ATP-dependent chromatin remodeler of the ISWI family, as essential gene for maintaining mitochondrial function, proliferation, and viability in HCC cells. Depletion of SMARCA5 led to severe impairments in …

    milano Repository record

  10. Rb pathway and chromatin remodeling genes that antagonize let-60 Ras signaling during C. elegans vulval development

    Ceol, Craig J. (Craig Joseph), 1971-Massachusetts Institute of Technology2003

    … homolog with class B synMuv activity, to remodel chromatin and repress transcription of genes that promote vulval development. To further understand how lin-35 Rb and hda-1 regulate vulval cell fate specification, we identified and characterized additional class B synMuv genes. We found that two …

    mit Repository record

  11. LDB-1 AND SWI/SNF CHROMATIN REMODELING COMPLEX PARTICIPATE IN THE TRANSCRIPTIONAL ACTIVATION BY C. ELEGANS BLIMP1/PRDM1

    FONG HEI TUNG2019

    Caenorhabditis elegans BLMP-1 is the ortholog of the human zinc finger and SET domain-containing transcriptional repressor BLIMP1/PRDM1. BLIMP1/PRDM1 and its orthologs are well studied as transcriptional repressors in many species including humans and mice. Interestingly, we found that in C. …

    nus Repository record

  12. Lysine Specific Demethylase-1 and the Brahma Chromatin Remodeling Complex Regulate Conserved Signaling Pathways During Drosophila Wing Development

    Curtis, Brenda Jean2016

    <p>The conserved SWI/SNF chromatin remodeling complex uses the energy from ATP hydrolysis to alter local chromatin environments by disrupting DNA-histone contacts. The Drosophila SWI/SNF counterpart, the Brahma complex, has been shown to have an essential role in regulating the proper expression of …

    loyola-thes Repository record

  13. CHARACTERIZING THE ROLE OF THE CHROMATIN REMODELING COMPONENT ARID1A AS A SUPPRESSOR OF SPORADIC MAMMARY TUMORS IN MICE

    Kartha, NithyaCornell University2017

    … heterozygous deletions of a gene encoding the chromatin remodeling component Arid1a. Importantly, ARID1A is also frequently deleted (monoallelically) in a significant subset of human breast cancers (between 30-50%, depending on the specific study cited), based on data from The Cancer Genome …

    cornell Repository record

  14. THE CELL CYCLE GENES REGULATION OF IPS CELLS AND THE ROLE OF SWI/SNF CHROMATIN REMODELING ENZYMES DURING THEM DIFFERENTIATION

    ROSSI, MAURIZIOUniversità degli studi di Catania2011

    Lo stato di cellula pluripotente può essere raggiunto con l'espressione ectopica di alcuni fattori di trascrizione che possono riprogrammare le cellule somatiche. (Takahashi, K., e Yamanaka, S., 2006; Takahashi, K., e Yamanaka, S., 2007).

    catania Repository record

  15. Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells

    Ganguly, Debolina2021

    … that BRG1, the catalytic component of the chromatin remodeling complex SWI/SNF, plays a critical role in the maintenance of the GICs and in the drug resistance of these cells. We show that BRG1 promotes the expression of key stem cell markers, Oct4, Nanog and CD44, while loss of BRG1 led to …

    tenn-hsc Repository record

  16. Generation and Characterization of a Knock-In Allele of EKLF: Probing the in vivo Role of the Chromatin Remodeling Domain in Definitive Hematopoietic Cells

    Jansen, Valerie Malyvanh2016

    … of EKLF (D221EKLF) is required to induce chromatin remodeling at the β-globin promoter in an EKLF-null erythroid cell line. However, additional amino terminal sequences are required for initiation of β-globin gene transcription. To evaluate the role of this chromatin remodeling domain in …

    tenn-hsc Repository record

  17. MECHANISMS OF CHROMATIN REMODELING BY ISWI FAMILY OF REMODELERS: A FUNCTIONAL AND STRUCTURAL INSIGHT INTO THE ROLE OF THE Itc1 SUBUNIT OF ISW2 REMODELING COMPLEX

    Prasad, Punit

    … and space nucleosomes. These ATP-dependent remodeling complexes have a relatively small number of subunits (2-4) as compared to other classes of remodelers such as SWI/SNF, RSC and INO80/SWR-C. The accessory subunits of some of the ISWI remodelers from yeast have been shown to contact …

    siu-theses Repository record

  18. Colocalization between Akirin, the NuRD Complex, and Histone Modifications

    Anglin, Sarah2027

    … mechanism remains unclear. Of the 4 major animal chromatin remodeling complexes, SWI/SNF, INO80, ISWI, and CHD, we know Akirin interacts with subunits of the SWI/SNF family Brahma (BRM) chromatin remodeling complex during myogenesis and cardiogenesis. Interaction between Akirin and CHD family …

    kennesaw Repository record

  19. Akirin-Mediated Gene Regulation During Cardiac Development

    Howard, Austin M2020

    … factor and the multisubunit Brahma SWI/SNF-class chromatin remodeling complex at control elements of the <em>Dmef2</em> locus to maintain optimal myogenic gene expression levels. Therefore, Akirin represents a class of novel secondary cofactors that work with transcription machinery to link …

    kennesaw Repository record

  20. Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming

    Smith, Derek Kurtis2018

    … SOX4 expression, and promote SOX4-dependent chromatin remodeling. Genome-wide occupancy analysis revealed that SOX4 targets numerous SWI/SNF complex subunits and co-binds with NEUROG2 to enhance the expression of diverse neurogenic factors. The overexpression of SWI/SNF chromatin remodeling …

    utswmed Repository record

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