Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"chromatin recruitment"”.
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Molecular Characterization of Mammalian De Novo DNA Methyltransferase Chromatin Recruitment
… and 3B (DNMT3B) is facilitated in part by chromatin "reader" domains to establish DNA methylation patterns genome-wide. Recent work has highlighted a role for the PWWP reader domain in directing recruitment of DNMT3B to actively transcribed gene bodies. However, our understanding of de novo …
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HISTONE-DEPENDENT AND HISTONE-INDEPENDENT PATHWAYS FOR RAD9 CHROMATIN RECRUITMENT AND CHECKPOINT ACTIVATION
… a structure that is responsible for the recruitment and activation of the apical kinase complex Mec1-Ddc2 and for the loading onto DNA of the 9-1-1 complex. Once activated, Mec1 phosphorylates different targets, among which Ddc2, the Ddc1 component of the 9-1-1 complex, histone H2A. …
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TOWARD STRUCTURAL INSIGHTS INTO THE RECOGNITION OF H3K27 TRIMETHYLATION BY CANONICAL PRC1
Polycomb group (PcG) proteins are chromatin modifiers that epigenetically regulate the transcription of key developmental genes involved in embryogenesis, pluripotency and tumorigenesis. Alterations in their activity are hallmarks in developmental disorders and cancer as chromatin modifiers are one …
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Study of the Gain-of-Function Mutant p53 and PARP1 in Triple-Negative Breast Cancer
… with replicating DNA and upregulates the chromatin localization of several DNA replication factors including PCNA, MCM2-7, and PARP1 (termed the mtp53-PARP-MCM axis). In this thesis, we explore the contribution of mutant p53 and PARP1 in castration-resistant prostate cancer (mutant p53 …
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Mechanisms of human RAD51 regulation by RAD52 and BRCA2
… damage. Moreover, RAD52 controls the chromatin recruitment and DNA assembly of RAD51, as well as subsequent HR-mediated DNA repair in BRCA2-deficient cells, but is dispensable for these processes in cells that are heterozygous or wild-type for BRCA2. In contrast, RAD52 protects nascent …