Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"chromatin modifiers"”.
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TOWARD STRUCTURAL INSIGHTS INTO THE RECOGNITION OF H3K27 TRIMETHYLATION BY CANONICAL PRC1
Polycomb group (PcG) proteins are chromatin modifiers that epigenetically regulate the transcription of key developmental genes involved in embryogenesis, pluripotency and tumorigenesis. Alterations in their activity are hallmarks in developmental disorders and cancer as chromatin modifiers are one …
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Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D
<p>The architecture of chromatin is complex and plays a substantial role in all of the biological processes involving DNA. In particular, transcriptional activation depends on the interplay of dozens of chromatin modifiers to establish an epigenetic landscape permissive of gene transcription. Among …
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Characterization of the Beta-Karyopherin Protein Ipo9 During Germ Cell Differentiation
… factors, signaling pathway effectors, chromatin modifiers and meiotic related proteins play fundamental roles during germ cell development. In order for these proteins to work they need to access the nucleus, through nuclear trafficking machinery. The karyopherin family of proteins is …
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Transposable elements and the regulatory logic of hematopoietic differentiation
… of gene expression by transcription factors, chromatin modifiers and cis-regulatory elements is central to establish cellular identity and function. Understanding this regulatory logic is critical for deriving select cell types in vitro for translational applications. The human hematopoietic …
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E2F6 in axial skeletal development and gliosis
… with the polycomb group (PcG) proteins and chromatin modifiers. PcG proteins regulate processes required for proper embryonic development and differentiation. E2F6 interacts with core components of Polycomb Repressive Complex 1 (PRC1) and participates in PcG-mediated repression of Hox genes. …
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Gcn5 Impacts Fgf Signaling At Multiple Levels and Activates C-Myc Target Genes During Early Differentiation of Embryoid Bodies
… often occurring. Growing evidence has identified chromatin modifiers as important regulators for development as well, yet how particular chromatin modifying enzymes affect specific developmental processes remains largely unclear. Embryonic stem cells (ESCs) are self-renewing, pluripotent, and have …
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EZH1 variants disrupt neurogenesis in hPSC-derived neuronal models and cause neurodevelopmental disorders
The disruption of chromatin modifiers during cortical neurogenesis is one of the underlying causes of neurodevelopmental and intellectual disability disorders. We recently found EZH1 loss and gain of function (LOF and GOF) variants as the genetic basis of overlapping novel neurodevelopmental …
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Chromatin-based memory of prolonged cold exposure in Arabidopsis thaliana
… to environmental conditions. In recent years, chromatin has emerged as an important player in orchestrating gene regulation. This thesis focuses on the role of chromatin in the maintenance of gene expression states and their inheritance through cell division. FLOWERING LOCUS C (FLC) in the …
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EPIGENETIC MECHANISMS OF POLYCOMB REPRESSIVE COMPLEX 1 IN INTESTINAL LINEAGE COMMITMENT
… cells (ESCs) (3). During intestinal homeostasis, chromatin modifiers play important roles in maintaining transcriptional signatures of specific cell types. Our group has already demonstrated that RING1A/B are necessary to maintain normal tissue homeostasis by preservation of the WNT/B-catenin …
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The Sec6/8 (a.k.a. Exocyst) Complex Supports DNA Repair Fidelity
… in part, through restraint of the associated chromatin modifiers ATF2 and RNF20. Exocyst perturbation resulted in aberrant accumulation of ATF2 and RNF20; the promiscuous accumulation of DDR-associated chromatin marks; and IR-induced increased Rad51 repairosomes. Thus, the exocyst indirectly …
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The Mi-2 Homolog Mit1 Actively Positions Nucleosomes Within Heterochromatin to Suppress Transcription
… complexes form a dynamic structure known as chromatin. Nucleosomes are the repeating unit of chromatin, and consist of DNA wrapped around an octamer of histone proteins. Nucleosomes can then be modified and spatially arranged to facilitate processes such as transcription, DNA replication, and …
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A chromatin-modifying protein is a context-dependent modulator of cell survival in hematopoietic malignancies
Proteins that modify chromatin architecture are important drivers of leukemia. Many genetic lesions in hematopoietic malignancies lead to altered function of one or more chromatin-modifying proteins, often resulting in less differentiated cells that are more therapy-resistant. While a number of …