Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"chromatin mobility"”.
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Characterization of a Novel 53BP1-Dependent Mechanism that Promotes Non-Homologous End Joining of Deprotected Telomeres by Increasing Chromatin Mobility
… (DSB) occurs in mammalian genomes, the local chromatin is altered through the modification of histones (notably the phosphorylation of H2AX) and the binding of DNA damage response factors (e.g. MDC1, 53BP1). Although several lines of evidence have pointed to a role for some of these factors in …
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Analysis of Interphase Chromatin Motion in HeLa Cells
… under light microscopy techniques. Variations in mobility of particles may give relevant biophysical information. Automated high resolution single particle tracking techniques were used to characterize interphase chromatin mobility in the cell nucleus. Interphase chromatin undergo replication …
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Biophysical Analysis of S100A12 and the Nucleosome Core Particle
<p>Calcium signaling and chromatin remodeling are fundamental regulatory processes that control protein activity and gene expression, respectively. This thesis investigates the molecular mechanisms by which local ligand binding and structural perturbations propagate allosteric effects across larger …
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Investigating the chromatin dynamics of gene activation
… previously unknown. I investigated changes in chromatin accessibility and modifications to show that Shh expression is activated from endodermal enhancers when mESCs are differentiated with retinoic acid. RNA-seq confirmed that the resulting cells express several markers of early endoderm and …
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Study of 3D Genome Organisation in Budding Yeast by Heterogeneous Polymer Simulations
… architecture is highly dynamic and significant chromatin re-organisation occurs in response to environmental changes. However, the mechanisms that drive the 3D organisation of the genome remain largely unknown. To understand the effect of biophysical properties of chromatin on the dynamics and …