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Showing 1 to 13 of 13 for “"chromatin biology"”.
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From Technology to Chromatin Biology: Contemporary Mass Spectrometry of Histones and Chromatin Associated Proteins
… of top down and middle down MS to other chromatin-associated proteins like HMGA1. In this study we were able to link PTM dynamics (phosphorylation of Ser 43) on HMGA1a to DNA repair and the early events in apoptosis.
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From Technology to Chromatin Biology: Contemporary Mass Spectrometry of Histones and Chromatin Associated Proteins
Made available in DSpace on 2014-12-17T21:58:34Z (GMT). No. of bitstreams: 1 3347511.pdf: 6286893 bytes, checksum: a541f3eac3d2d43e52f4e03c2218cf78 (MD5) Previous issue date: 2008
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Single-Molecule Investigation of Chromatin-Associated Factors in Genome Organization and Epigenetic Maintenance
<p>The central dogma of biology has laid the foundation for understanding gene expression through the mechanisms of transcription and translation. However, another layer of eukaryotic gene regulation lies in the complex structure of chromatin. This scaffold of structural proteins and enzymatic …
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Investigations into the Role of Paf1 Complex Proteins in Drosophila Ovaries
… interest has grown in epigenetics and chromatin modifications. The ability of two cells with identical genomes to have entirely different transcriptomes and therefore cellular behaviors has piqued the curiosity of many researchers creating the whole field of Chromatin Biology. The …
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Regulation and function of histone variant H2BE in neurons
… of H2A and H3 have well defined roles in chromatin regulation, widely expressed variants of H2B remain elusive. Further, while recent findings link histone variants to neurological disorders, few are well-studied in the context of the brain. The work described here combines multiomic …
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Postmitotic Dynamics in Chromatin Modification and Regulatory Topology Underlie Cerebellar Granule Maturation
… This is mediated at least in part by dynamics in chromatin biology, as mutations in chromatin regulators are strongly implicated in the advent of neurodevelopmental and neuropsychiatric disorders. The mechanisms by which chromatin dynamics orchestrate neuronal maturation remain poorly understood. …
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Dissecting the Architectural Properties of Chromatin and the Influence of the H1 Linker Histone on Chromatin Regulation
… this research, I used an existing coarse-grained chromatin model from the Collepardo Lab to study the binding of the H1 linker histone to chromatin and delve into the intrinsic properties of chromatin that regulate its architecture. The primary aim is to decipher the factors modulating chromatin …
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Roles of the Histone Chaperone FACT in Drosophila Gene Regulation and Chromatin Architecture
… conserved histone chaperone FACT (Facilitates Chromatin Transcription) is thought to contribute to the disassembly and reassembly of nucleosomes in the wake of RNA polymerase II passage through chromatin. In yeast, mutation of FACT subunits leads to decreased nucleosome occupancy at the …
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TET1 AND TRANSCRIPTION FACTOR REGULATION OF LINEAGE SPECIFICATION DURING MOUSE GASTRULATION AND EARLY ORGANOGENESIS
… and proteomic screens for TF regulators and chromatin-bound TET1 proximal (“proxisome”) proteins, I use experimental perturbations to determine novel lineage-driving TFs and TET1 epigenetic mechanisms that drive this period of development. In Chapter 1, I review recent findings in the …
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Studies of the MYM-type zinc finger protein ZMYM3
… work, I identify several members of a putative chromatin-silencing complex as novel RNase H2B binding partners whose binding is impaired by each mutation in this cluster, including: HDAC2, a histone deacetylase, LSD1, a histone demethylase, CoREST, a co-repressor of transcription, TFII-I, a …
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Paraspeckle protein NONO regulates active chromatin by allosterically stimulating NSD1
… 36 (H3K36) and lysine 27 (H3K27) defines euchromatin and facultative heterochromatin, respectively, thereby distinguishing transcriptionally active from repressive chromatin domains. These modifications are catalyzed by distinct families of histone methyltransferases: the Nuclear …
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Regulation of the Alpha and Delta T Cell Receptor Repertoires
… We and others have previously demonstrated that chromatin topology has a major impact on transcription and V(D)J recombination. Control of locus conformation is heavily influenced by contacts between CCCTC binding factor (CTCF)-bound elements. How CTCF regulates recombination at the Tcra-Tcrd …
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A role for environmental epigenetics in the rapid diversification of East African cichlid fishes
… interaction is a central feature of regulatory biology. By definition, phenotypic plasticity involves a change in gene regulation. These gene regulatory transitions are commonly mediated by an array of epigenetic mechanisms, which exert dynamic, environmentally responsive control over the …