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Showing 1 to 9 of 9 for “"chorismate mutase"”.
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Yeast Chorismate Mutase: Molecular Evolution of an Allosteric Enzyme
Die Chorismatmutase (CM, EC 5.4.99.5), kodiert durch ARO7, katalysiert die Claisen-Umlagerung von Chorismat zu Prephenat in der Biosynthese von Tyrosin und Phenylalanin. Das relativ kleine, dimere Enzym der Hefe Saccharomyces cerevisiae wird allosterisch durch Tryptophan aktiviert und allosterisch …
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Mechanistic studies on chorismate mutase-prephenate dehydrogenase from E. coli
Chorismate mutase-prephenate dehydrogenase is a bifunctional enzyme that catalyzes two sequential reactions in the biosynthesis of tyrosine in E. coli and other enteric bacteria. Chorismate mutase catalyzes the pericyclic rearrangement of chorismate to prephenate which is subsequently converted to …
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Syntheses of chorismate analogs for investigation of structural requirements for chorismate mutase
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Biomolecular ligand design : enhancing binding affinity and specificity utilizing electrostatic charge optimization and packing techniques
… state analog (TSA) binding to the E. coli chorismate mutase enzyme was performed. This study included an electrostatic component analysis of both the ligand and receptor to understands the determinants of binding as well as an optimization of the TSA charges that revealed that the system …
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Large scale quantum mechanical enzymology
… the reaction pathway for the Bacillus subtilis chorismate mutase (CM) enzyme is made. Averaged energies of activation and reaction are presented for the rearrangement of chorismate to prephenate in CM and in water, for system sizes comprising up to 2000 atoms. Compared to the uncatalysed …
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A combinatorial approach for improved target prediction, validation, and characterization of small RNAs in Escherichia coli
… found that RydC represses pheA, which encodes a chorismate mutase and is involved in phenylalanine biosynthesis, and activates trpE, encoding an anthranilate synthase involved in tryptophan biosynthesis. In addition to the minor RydC role in biofilm formation and sugar transport, we were able to …
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Mechanistic and Structural Studies of Salicylate Biosynthesis in Pseudomonas aeruginosa
… aeruginosa, uses salicylate derived from chorismate as a precursor. Studies have shown that the salicylate activation by adenylation for incorporation to siderophores is associated with the growth and virulence of some pathogens. The inhibition of salicylate biosynthesis, and hence, …
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Plant-parasitic nematodes: from genomics to functional analysis of parasitism genes
Nematodes (roundworms) belong to the largest phylum on earth. The numerous species inhabit practically all ecological niches, including plants. Plant-parasitic species live on plant roots, causing substantial damage to the plant and hampering its development. As such, they cause gigantic economical …