Global ETD Search
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Showing 1 to 8 of 8 for “"chondroitin sulfate proteoglycans"”.
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In vitro detection of cues that guide thalamocortical development : a role for chondroitin sulfate proteoglycans
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1996.
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Neurite inhibiting factors from the developing and mature spinal cord
… components of the extracellular matrix, heparan sulfate and chondroitin sulfate proteoglycans, were also examined for changes over the developmental period encompassing the transition from permissive to restrictive periods for spinal cord repair. The ratio of neurite promoting heparan sulfate …
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Identification of the receptor for cellular internalization of an anti-nucleic acid antibody, 3D8 scFv
… 3D8 scFv bound to both cell surface heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) that are highly negatively charged molecules known as endocytic receptors for a variety of ligands. Treatment of soluble HS or CS reduced cell surface binding of 3D8 scFv to …
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… that interfere with the remyelination response. Chondroitin sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules that provide structural rigidity to tissues and act as signalling molecules to neurons and glia in the developing nervous system. After injury, CSPGs become …
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… and extrinsic obstacles. Following injury, chondroitin sulfate proteoglycans (CSPGs) accumulate within the glial scar that forms at the lesion site in response to the insult. CSPGs inhibit axonal growth and regeneration, an action mediated by their sulfated glycosaminoglycan (GAG) chains, …
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hepatocyte growth factor inhibits glial scar formation and
… Glial scars also produce various species of chondroitin sulfate proteoglycans (CSPGs) that act as a potent inhibitor of axon growth. Thus, inhibition of glial scar formation and/or suppression of CSPGs production may support axonal regeneration following spinal cord injury. Hepatocyte growth …
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Restoring bladder function by promoting neuronal regeneration
… of an inhibitory environment produced in part by chondroitin sulfate proteoglycans (CSPGs) manufactured by reactive astrocytes and oligodendrocytes. We examined the influence of the GDNF family neurotrophin artemin on the neuroarchitecture and extracellular matrix composition of the dorsal spinal …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… BMP4 potentiates the deposition of inhibitory chondroitin sulfate proteoglycans (CSPGs) by reactive astrocytes in vitro, and this can be attenuated with noggin or LDN193189 treatments in SCI rats. Despite these early benefits, our work reveals that acute inhibition of BMP antagonism was not …