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Showing 1 to 20 of 110 for “"chondrocyte"”.
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Chondrocyte biomechanics and chondrogenesis
… the biomechanical characteristics of single chondrocytes, and tissue engineering musculoskeletal cartilages with human embryonic stem cells (hESCs). Both of these areas of investigation are motivated by the significant economic and social burdens of cartilage afflictions. Mechanical forces …
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The role of mechanical loading in chondrocyte signaling pathways
<p>Chondrocytes are a predominant cell type present in articular cartilage, whose integrity is jeopardized in joint degenerative diseases such as osteoarthritis (OA). In the chondrocytes of patients with OA, the elevated levels of inflammatory cytokines such as interleukin 1β (IL1β) and tumor …
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Investigating the causes of chondrocyte death in septic arthritis
… explanation for the clinical results is that chondrocyte death could occur during septic arthritis. Chondrocytes are required to maintain healthy articular cartilage and in their absence degenerative change would be expected to accelerate. The predominant cause of damage appears to be related …
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Effect of simple preservation treatments on porcine chondrocyte isolation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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The effect of mechanical compression on chondrocyte gene expression
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1999.
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Chondrocyte gene expression and intracellular signaling pathways in cartilage mechanotransduction
Chondrocytes respond to in vivo mechanical loads by regulating the composition of the cartilage extracellular matrix. This study utilized three loading protocols that span the range of forces and flows induced by in vivo loading. Constant (static) compression of cartilage explants induces a …
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The Role of Piezo1 in Mediating Chondrocyte Cell Signaling and Senescence
… in OA progression via calcium signaling in chondrocytes. This study investigates the role of conditional Piezo channel knockout (cKO) in modulating calcium signaling and senescence in OA, particularly under the supra-physiologic inflammatory condition of a high-fat diet (HFD). Using calcium …
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Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature
Chondrocytes within articular cartilage possess the capacity to perceive and react to signals generated by the typical load-bearing actions of daily life, such as walking or running. Articular cartilage is predominantly oriented toward compression-based functionality, and thus the application of …
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The role of DEL1 in chondrocyte expansion and mechanotransduction: an investigative study
Matrix-induced autologous chondrocyte implantation offers a potential cure for joint disease and is currently challenged by loss of differentiated phenotype upon culture. To investigate the mechanism of dedifferentiation, chondrocytes were cultured at low density (1x104cell/cm2) and subcultured on …
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Articular cartilage--matrix assembly, mediation of chondrocyte metabolism, and response to compression
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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Regulation of chondrocyte biosynthesis in epiphyseal cartilage--the role of interstitial pH
Thesis: M.S., Massachusetts Institute of Technology, Department of Mechanical Engineering, 1991
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The effect of dynamic shear force on chondrocyte biosynthesis in agarose gels
… nature of cartilage, its native cells (chondrocytes) have limited regeneration capabilities after injury. Previous investigators discovered that dynamic compressive loading can increase cell biosynthesis in cartilage explants as well as in hydrogels such as agarose and self-assembling …
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Progression of chondrocyte signaling responses to mechanical stimulation in 3-D gel culture
Mechanical stimulation of 3-D chondrocyte cultures increases extracellular matrix (ECM) production and mechanical stiffness in regenerating cartilage. The goal of this study was to examine the progression of chondrocyte signaling responses to mechanical stimulation in 3-D culture during tissue …
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Chondrocyte metabolism and matrix nano-electromechanics : the response to cartilage tissue shear deformation
… that varies with the rate of deformation. Chondrocytes synthesize and degrade matrix components influenced by the regulatory signals present in the extracellular matrix. The transduction mechanisms by which mechanical signals are converted to a biological response are not completely …
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Chondrocyte response to in vitro mechanical injury and co-culture with joint capsule tissue
… matrix damage and decreased biosynthesis by the chondrocytes. We measured gene expression levels of matrix molecules and matrix proteases and found them to be expressed in control cartilage at levels ranging over five orders of magnitude, and to be differentially regulated in these three models …
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Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors
… of extracellular matrix (ECM) by articular chondrocytes (ACs). Two important hormonal regulators of cartilage metabolism are interleukin-1 (IL-1) and insulin-like growth factor-I (IGF-I). These factors have antagonistic effects on chondrocyte activity, and during the progression of …
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Exploring Chondrocyte Integrin Regulation of Growth Factor IGF-I Expression from a Transient pAAV Vector
… mitogenic and anabolic responses in articular chondrocytes. While it has been shown that exogenous IGF-I can regulate chondrocyte integrins, little is known regarding regulatory effects of IGF-I produced from a transiently expressed plasmid based adeno-associated virus (pAAV) vector. Because …
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