Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"cholinesterase inhibitor"”.
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Changes in cerebral glucose metabolism in patients with Parkinson’s disease with dementia after cholinesterase inhibitor therapy
… disease dementia (PDD) patients after cholinesterase inhibitor therapy. BACKGROUND: Cholinesterase inhibitors (ChEI) are now widely used with proven efficacy in patients with PDD. There have been several reports describing how the drugs are benefiting the PDD patients in terms of …
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Long Term Outcome and Prediction Models of Cognition, Activities of Daily Living and Nursing Home Placement in Alzheimer’s Disease with Cholinesterase Inhibitor Treatment
… studies in Alzheimer's disease (AD) that include cholinesterase inhibitor (ChEI) treatment in routine clinical settings are scarce. The patients vary in severity of the disease, clinical course, rate of progression and response to treatment. Knowledge about the predicted course of the disease, …
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Changes in Brain Functional Connectivity Following Donepezil Treatment in Alzheimer's Disease
… disease (AD) following treatment with the cholinesterase inhibitor, donepezil. The ROIs were selected on the basis of their association with cholinergic neurotransmission, AD neuropathology, and neurocognitive deficits in AD. These ROIs included the medial septal nuclei, left and right …
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Anatomy of visual hallucinations and fluctuations of consciousness in Lewy body diseases
… without visual hallucinations. A drug trial of a cholinesterase inhibitor in this population was then performed to determine clinical effect and the impact of this drug on cerebral perfusion. These studies identified occipital hypoperfusion in Parkinson's disease patients with visual …
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Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
… unc-73 RhoGEF2 mutants are resistant to the cholinesterase inhibitor aldicarb and are hypersensitive to the cholinergic agonist levamisole, without any obvious changes in synaptic structure based on the localization of fluorescence-tagged synaptobrevin. These results suggest that the UNC-73 …
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Cognitive impairment: quantification and possibilities for pharmacological treatment
… atomoxetine, a noradrenaline reuptake inhibitor. A double-blind placebo-controlled study revealed that atomoxetine may be a candidate for treatment of response inhibition impairments seen in PD. This finding is important as noradrenergic treatments are not currently used in PD, despite …
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Synthesis and evaluation of novel multi-target compounds for the treatment of Alzheimer's disease.
… with an aromatic system, which could act as a cholinesterase inhibitor or prevent the aggregation of toxic proteins, were developed and fully characterised. The multi-target activity of these novel compounds was evaluated in vitro, and select compounds demonstrated potent antioxidant and …
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Design, development, and evaluation of novel polymer-drug conjugates and interpolymer complexes for the treatment of neurodegenerative disease.
… driven by oxidative stress (OS) and increased cholinesterase activity. Current treatments are mainly symptomatic and target single pathways, offering limited impact on disease progression. Increasingly, multi-target therapies are being considered more effective for addressing the multifactorial …
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Wirelessly addressable chemiresistors : carbon nanotube-based chemical sensors and dosimeters
… (DCP), a model organophosphorous cholinesterase inhibitor simulant. To provide selective and readily manufacturable sensor elements, we developed an ionic liquid-mediated single walled carbon nanotube based chemidosimetric scheme capable of detecting DCP across a broad dynamic …
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Donepezil’s Effect on Cardiac Function in Patients with Alzheimer’s Disease through an In Vivo, Non Invasive Measure of Cardiac Autonomic Function
<p>The aim of the current study was to explore the effects of the medication Donepezil (Aricept®) on cardiac autonomic function for individuals diagnosed with mild to moderate (probable) Alzheimer’s disease (AD). Using age (± 3 years) and gender matched controls, differences in heart rate …
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Long-term treatment response, predictors and biochemical markers in Alzheimer’s disease.
… AD. This has been a target for therapy since the cholinesterase inhibitors (ChEIs) (tacrine, donepezil, rivastigmine, galantamine) were introduced as treatments for AD. Multiple short-term randomised clinical trials of ChEI treatment show beneficial effects on cognition, global functioning and …
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Präsynaptische Wirkungen von Cholinesterase-Hemmstoffen im Neocortex des Menschen und der Ratte
… wird auch heute noch hauptsächlich mit <br>Cholinesterase-Hemmern (AChEI) behandelt. Diese könnten jedoch auch indirekt - <br>nach der angestrebten Erhöhung der endogenen ACh-Spiegel - über muskarinische <br>Autorezeptoren die ACh-Freisetzung im Gehirn verringern. Um diesen klinisch …