Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"cholinergic system"”.
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COGNITIVE DECLINE WITH AGE: ROLE OF STRIATAL CHOLINERGIC SYSTEM AND GROWTH HORMONE
Normal aging can result in cognitive decline even in the absence of neurodegenerative disease. Successful identification of neurobiological changes that occur in association with age-related cognitive decline is needed to develop strategies to restore or preserve cognitive function in elderly …
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Retrieval induced forgetting in depression and schizophrenia: role of mood and the cholinergic system
… however there is evidence that mediation of the cholinergic system with nicotine increases RIF whilst low mood reduces the RIF effect. In a series of studies, selected neuropsychological measures, RIF, smoking status and mood were assessed in a sample of individuals with clinical depression, …
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The role of the cholinergic system in the anticonvulsant effects of the barbiturates and other anticonvulsants
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The role of Lynx1, an endogenous modulator of cholinergic transmission, in NMJ development, maintenance, and repair
The cholinergic system drives muscle contraction and plays a central role in the formation, maintenance, and repair of mammalian neuromuscular junctions (NMJs) and skeletal muscles. Because of these essential actions, much effort has been devoted to identifying primary and auxiliary modulatory …
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Interactions between the cholinergic and dopaminergic system during the production of ultrasonic vocalizations in rats
… agents injected into the ascending mesolimbic cholinergic system that terminates in the anterior hypothalamic-preoptic area (AH-MPO) and lateral septum (LS). The other group of USVs contains 50-kHz USVs, characterized by high peak frequency, ranging from 39 to 90-kHz, short duration ranging …
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Acquisition and retention of an active avoidance response to intense white noise: Kamin effect
… 3 demonstrated that scopolamine, an anticholinergic drug, alters the typical U-shaped avoidance function whereas methylscopolamine, an anticholinergic which produces the same peripheral effects as scopolamine but passes the blood-brain barrier poorly, does not. These results suggested …
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Autoradiographic Localization of Carbachol-Induced Second Messenger Response in the Rat Spinal Cord Following Inflammation.
… and provide evidence for the involvement of cholinergic systems in this process. Because spinal cholinergic systems have been reported to be anti-nociceptive, the present results appear to reflect an upregulation of anti-nociceptive activity in response to inflammation. Thus, the spinal …
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Cholinergic signals promote the quiescence of normal or leukaemic stem cells through the activation of the α7-nicotinic receptor in bone marrow mesenchymal stromal cells
The sympathetic nervous system has evolved to respond to stress and activates haematopoietic stem cells (HSCs) using noradrenergic signals. However, the pathways that maintain HSC quiescence and maintenance during proliferative stress are not well understood. This study has investigated the role of …
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From the body to the brain: Studying drug delivery and physiological interactions using MRI
… connect the peripheral and central nervous system, and complex vasculature networks selectively permit passage of small molecules with an exogenous origin into the brain parenchyma. Although brain-body interactions underpin a host of cognitive and physiological phenomena, they are often …
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A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… MPTP was neurotoxic to the dopaminergic system, inhibiting monoamine oxidase (MAO) activity, and decreasing levels of dopamine (DA) and other catecholamines. In addition, MPTP enhanced ³H-DA release from cells, and its metabolite MPP⁺ inhibited ³H-DA uptake. MPTP was found to directly act …
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CHOLINERGIC CONTRIBUTIONS TO EMOTION REGULATION
… neuroanatomical studies implicate the muscarinic cholinergic system in normal and pathological emotion regulation. Emotional and sensory experiences can be induced with intravenous administration of the local anesthetic procaine hydrochloride, which selectively activates limbic regions in humans …
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Role of prefrontal cortex and cholinergic modulation in attentional performance in rats
… the role of the prefrontal cortex and cholinergic modulation in attentional performance, and to a lesser extent, inhibitory response control, in rats. A greater understanding of these functions is important for the effective treatment of attentional and impulsive control deficits, …
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Neurochemical Effects of Concurrent Exposure to Repeated Stress and Chlorpyrifos on the Central Nervous System
… impairment to the hippocampus. Glutamatergic and cholinergic systems were proposed to be involved in responses seen after exposure to stress and cholinesterase inhibitors. Effects of concurrent exposure to repeated stress and chlorpyrifos (CPF) on concentrations of excitatory amino acids, …
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The Development of Microelectrochemical Choline and Acetylcholine Biosensors for Real-Time Neurochemical Monitoring
… as a result of manipulations of aspects of the cholinergic system were undertaken using HC-3, neostigmine and atropine. The choline biosensor was characterised in both the in-vitro and the in-vivo environment and demonstrated detection of choline in the striatum of a freely moving rat. This …
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Συναπτική δράση παραγώγων νευροδιαβιβαστών και αντιεπιληπτικών φαρμάκων στον εγκέφαλο φυσιολογικών και επιληπτικών πειραματοζώων
… the following questions: 1) The function of cholinergic system in the cerebral cortex (through determination of the activity and kinetic properties of enzyme ChAT). 2) The physiological neuronal excitability and its changes due to: a) the increase (+2mM) of extracellular Κ⁺, b) the activation …
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Characterising hippocampal replay in the APP<sup>NL-G-F</sup> mouse model of Alzheimer’s disease
… into cortical networks, a process known as system-level consolidation. Replay, the rapid recapitulation of neural sequences experienced during behaviour, is thought to be a key mechanism supporting consolidation and predominantly occurs during rest and sleep. More generally replay is also …
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Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… innervated by sympathetic noradrenergic and cholinergic nerve fibres. While several studies suggest the bone-catabolic nature of noradrenergic innervation in decreasing osteoblast activity and promoting osteoclastogenesis, there is little known on the development and function of skeletal …
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Ontogeny of contextual fear conditioning: behavioral, neuropharmacological and molecular mechanisms
… & Klintsova, 2008). Additionally, impaired cholinergic function contributes to the learning impairment observed in the CPFE following alcohol exposure (Dokovna et al., 2013). The final experiment examined the specific contribution of the mPFC cholinergic system to each phase of the CPFE in …