Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"cholinergic neurotransmission"”.
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A role for focal adhesion kinase in the contraction of gastric fundus smooth muscle evoked by cholinergic neurotransmission
… gastric smooth muscles contractile regulation in cholinergic neurotransmission by FAK phosphorylation (Chapter 2) and (2) characterizing the change in Ca2+ sensitization proteins distribution at focal adhesion sites under electric field stimulation induced cholinergic neurotransmission and FAK …
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HISTAMINERGIC H3 AND CANNABINOID CB1 RECEPTORS IN DEMENTIA
… CB1 inverse agonists are co-administrated with cholinergic neurotransmission enhancements.
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Consuming a diet enriched with choline, UMP, and DHA improves memory in rodents when these compounds increase phospholipids
… animals increases synaptic membrane and cholinergic neurotransmission. This treatment involves giving three compounds; DHA, a phosphatide precursor; choline, another phosphatide precursor present in the rodents' diets but not varied in this study; and UMP, a precursor of CTP, the …
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Investigation of an unusual GABA-A receptor: studies on the promiscuous ε [epsilon] subunit
… release. In Alzheimer’s disease, cholinergic neurotransmission is reduced; therefore, this subtype might be a target for the development of anti-Alzheimer’s disease drugs that would function by increasing acetylcholine release in forebrain regions where cholinergic neurons are …
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Mild and Convenient Methods to Prepare N-Alkyl Tacrines
… (ACh). Observation of a deficiency of cholinergic neurotransmission in AD led to the development of AChEI as the first approved treatment for dementia symptoms. Tacrine (9-amino-1,2,3,4-tetrahydroacridine) is a reversible inhibitor of AChE. It was the first drug approved by the FDA for …
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Non-Photic Phase Shifting: Acetylcholine and Arousal
… also participate in non-photic phase shifting. Neurotransmission of acetylcholine (ACh) is involved in bringing about arousal and also has been shown to play a role in the circadian system. The purpose of these experiments was to determine if ACh plays a role in non-photic phase shifting and to …
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Changes in Brain Functional Connectivity Following Donepezil Treatment in Alzheimer's Disease
… selected on the basis of their association with cholinergic neurotransmission, AD neuropathology, and neurocognitive deficits in AD. These ROIs included the medial septal nuclei, left and right hippocampi, left Broca's area and its right hemisphere homologue, left and right dorsolateral …
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Cholinergic enhancing strategies and brain neuroplasticity. From preclinical evidence to clinical applications.
Cholinergic precursors have represented the first approach to counter cognitive impairment occurring in adultonset dementia disorders. In preclinical studies choline alphoscerate increases the release of acetylcholine in rat hippocampus, facilitates learning and memory in experimental animals, …
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Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
… from H. contortus are sensitive to various cholinergic ligands, nicotinic acetylcholine receptor anthelmintics, classical antagonists, and minimally sensitive to nicotine. Although one particular subunit, ACC-1, does not form a functional channel alone, it does associate with other members …
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Changes in cerebral glucose metabolism in patients with Parkinson’s disease with dementia after cholinesterase inhibitor therapy
… restores cognitive function by enhancing cholinergic neurotransmission in certain common areas regardless of the underlying pathologic process.
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Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase
Acetylcholinesterase (AChE) terminates cholinergic neurotransmission by catalyzing the hydrolysis of the neurotransmitter acetylcholine (ACh). Inhibition of AChE has proven an effective treatment for the memory loss exhibited by early stage Alzheimer's disease (AD) patients; four AChE inhibitors …
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Plasticity of neurons in mouse major pelvic ganglia in response to loos of physiological input in cases of nerve injury and spinal cord injury
… one MPG on each side of the animal. MPG receives cholinergic parasympathetic input from the preganglionic neurons in the sacral cord through pelvic nerve and sympathetic cholinergic inputs from those in the lumbosacral cord through the hypogastric nerve. Nicotinic cholinergic transmitter system is …
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Fear Learning and the Olfactory Bulb: Neural Correlates of Behavioral Fear Generalization
… OB during olfactory fear learning established cholinergic neurotransmission can enhance the strength of learned fear and that signaling through muscarinic receptors is required for the formation of olfactory fear. Gene expression analysis revealed that several neurotransmitter receptors are …
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Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… by exogenously applied 1ìM or 10ìM CCh or by cholinergic nerve stimulation (1, 5, 10, and 20 Hz). During the contraction induced by either method, smooth muscle strips were frozen at different phases of the contractile trace (upstroke, peak and plateau) and analyzed for the increase in CPI-17, …