Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"cholinergic neurons"”.
-
Mouse cortical cholinergic neurons: Ontogeny of phenotypes in vivo and in vitro.
The development of cholinergic neurons in mouse frontal cortex was studied both in vivo and in vitro by immunocytochemistry with an antibody to choline acetyltransferase (ChAT), the enzyme responsible for acetylcholine synthesis. While cortical cholinergic neurons have previously been characterized …
-
Selective Lesion of Cholinergic Neurons of the Septal-Hippocampal Tract: Memory and Learning
It is hypothesized that the loss of cholinergic function in the medial septum (MS), observed early in many forms of dementia, contributes to memory losses characterized in these diseases. The studies of this dissertation examined whether the selective loss of cholinergic neurons in the MS impairs …
-
Tetracycline-dependent gene expression in cholinergic neurons of transgenic mice : a tool to study Neuregulin-1 function in vivo
… this thesis. NRG1 is expressed by virtually all cholinergic neurons, therefore the choline acetyltransferase (ChAT) gene was selected to direct the expression of the tetracycline-dependent transactivator (tTA2S) to cholinergic neurons. In order to increase the likelihood that all required …
-
Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
… AT8 recognizes tau phosphorylation 11 H. Cholinergic dysfunction in the basal forebrain in AD cases 12 I. FTDP-17 13 J. Cholinergic dysfunction in P301L transgenic mice 14 Ⅱ. MATERIALS AND METHODS 16 1. Animals 16 2. Antibodies 16 3. Immunohistochemistry 16 4. Thioflavin-S staining 17 5. …
-
Functional relationship between forebrain cholinergic projections and somatostatin neurons in the rat
… degenerate with Alzheimer's Disease are the cholinergic projections from the septum to the hippocampus and from the substantia innominata to the cortex, and the somatostatinergic neurons in the hippocampus and cortex. The functional relationship between these two types of neurons was …
-
Forebrain Acetylcholine in Action: Dynamic Activities and Modulation on Target Areas
<p>Forebrain cholinergic projection systems innervate the entire cortex and hippocampus. These cholinergic systems are involved in a wide range of cognitive and behavioral functions, including learning and memory, attention, and sleep-waking modulation. However, the <italic>in vivo</italic> …
-
The Role of Neuronal Leak Channels in Anesthesia
… bychannelrhodopsin-2 based depolarization of the cholinergic neurons.Furthermore, hyperpolarizing cholinergic neurons via halorhodopsin activationincreases sensitivity to halothane. Immobility induced by isoflurane, a structurallysimilar anesthetic, is not affected by optogenetic manipulation of …
-
MUSCARINIC ACETYLCHOLINE M2 RECEPTORS INCREASE IN CHOLINERGIC INTERNEURONS OF THE NUCLEUS ACCUMBENS FOLLOWING BINGE ALCOHOL DRINKING IN C57BL/6J MICE
… concentration, the present study examined the cholinergic interneurons in the nucleus accumbens, a brain region that is affected by drugs of abuse including alcohol. Cholinergic interneurons in the nucleus accumbens were of particular interest in this study since previous findings have reported …
-
Interactions of Thyroid Hormones and Nerve Growth Factor in Normal Development of the Rat Hippocampus and Basal Forebrain and in Recovery From Early Hypothyroid Retardation
… in decreased trophic support for basal forebrain cholinergic neurons, leading to a compensatory up-regulation of NGF receptors. Thyroid hormone normalization restores total hippocampal NGF, causing hypertrophic growth responses in both the basal forebrain and hippocampal formation. Our findings …
-
The Effect of Selective Cholinergic Lesion of Medial Septum on Recognition Memory
… was to clarify the role of septal-hippocampal cholinergic neurons in object and spatial recognition memory. Stereotaxic-surgical infusion of the selective cholinergic neurotoxin, 192IgG-saporin (SAP), into the medial septum (MS) of Sprague-Dawley rats was utilized to establish an animal model …
-
Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… decrease in nerve growth factor (NGF)-responsive cholinergic neurons. I report a synergistic effect of the cytokine tumor necrosis factor alpha (TNFa) and NGF on expression of nitric oxide synthase (NOS), in rat pheochromocytoma PC12 cells. NGF/TNFa-promoted iNOS can be toxic in PC12 cells. Using …
-
Investigation of an unusual GABA-A receptor: studies on the promiscuous ε [epsilon] subunit
… contains the α3 and ε subunits, is present in neurons within the forebrain that synthesise acetylcholine, and this may regulate neurotransmitter release. In Alzheimer’s disease, cholinergic neurotransmission is reduced; therefore, this subtype might be a target for the development of …
-
Cholinergic Control of Cortical Circuit Activity
<p>Cholinergic neurons of the basal forebrain send extensive projections to all regions of the neocortex and are critically involved in a diverse array of cognitive functions, including sensation, attention and learning. Cholinergic signaling also plays a crucial role in the moment-to-moment …
-
Habituation and Dishabituation in the Olfactory Bulb: From Neural Responses to Behavior
… behaving mice. Optogenetic stimulation of OB cholinergic neurons rapidly modulated odor salience in this paradigm, causing mice to suddenly investigate a previously ignored odor. Non-olfactory sensory stimulation also dishabituated odor investigation and this increase could be blocked …
-
Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… is essential for developing new therapies. Cholinergic signals have been shown to stimulate mucus secretion, but the mechanism is not fully understood. The aim of this study was to investigate the molecular mechanism of calcium (Ca2+) coupling mucus (MUC2) secretion in colonic goblet cells …
-
Non-Photic Phase Shifting: Acetylcholine and Arousal
… it was found that Fos expression specifically in cholinergic cells of the forebrain is increased in animals undergoing novel wheel confinement, but not sleep deprivation. It was then found that in vivo electrical stimulation of the basal forebrain region containing cholinergic neurons phase …
-
Investigating the neurobiology regulating cognitive effort allocation using a rodent model of cost/benefit decision making
… 1, I use chemogenetics to downregulate cholinergic neurons of the basal forebrain as rats perform the rCET, to determine whether this neuronal population is responsible for the previously ascribed role of acetylcholine in regulating decision making with cognitive effort costs. …
-
Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… innervated by sympathetic noradrenergic and cholinergic nerve fibres. While several studies suggest the bone-catabolic nature of noradrenergic innervation in decreasing osteoblast activity and promoting osteoclastogenesis, there is little known on the development and function of skeletal …
-
Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… into choline acetyltransferase (ChAT) motoneurons in vitro and after transplantation into the rodent spinal cord in vivo. However, the mechanisms surrounding FHL-induced motoneuron differentiation of hNSCs are unknown. Thus, the overall goal for this thesis was to further understand the …
-
Humna fetal neural stem cells: Proliferation and differentiation in response to growth factors and role in locomotor recovery after spinal cord contusion injury
… (FHL). Particularly, significant generation of cholinergic cells was observed only in hNSCs expanded with EGF/bFGF or EGF/bFGF/LIF, but not with other treatment regimens. \r\nSubsequently, we examined the effect of temporal transplantation of hNSCs into contusion injured rat spinal cords. …
Page 1 of 2