Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cholesterol-dependent cytolysin"”.
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Activation State of Human T and NK Cells Increases Sensitivity to Death by Streptococcus pneumoniae
… and to evade the host immune system. PLY is a cholesterol-dependent cytolysin and has been shown to be a major virulence factor. In this study, we investigated the hemolytic activity of Spn lysates of several different pneumococcal serotypes. We showed the hemolytic activity of Spn correlated …
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Protein engineering for cancer therapy
… The use of a second agent that contains the cholesterol dependent cytolysin, perfringolysin 0, enhances endosomal escape of siRNA. Targeted delivery of perfringolysin 0 induces gene silencing in a dose-dependent and EGFR-dependent manner. However, cytotoxicity of the cytolysin creates a …
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Reversibly neutralized perfringolysin O for intracellular delivery of macromolecules/
… Perfringolysin O (PFO) is a member of the cholesterol-dependent cytolysin (CDC) family of bacterial toxins whose pores, reaching up to 30nm in diameter, allow the passage of large molecules without a specialized transport mechanism. However, the creation of such pores on the cell membrane …
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Characterization Of Streptolysin O As The Translocator For The Cytolysin-Mediated Translocation Process In Streptococcus Pyogenes
… illustrate that SLO pore formation can occur independently of SPN secretion and that there is a synergistic effect between these two SLO activities. Further studies using pharmacological inhibitors to probe the involvement of the host cell during CMT indicate that clathrin-dependent endocytosis …