Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"cholesterol synthesis"”.
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Cholesterol synthesis inhibitors prevent growth and metastasis of breast cancer cells
… hitherto considered as simply an inhibitor of cholesterol biosynthesis, clearly possesses potent anti-cancer effects. Its potential as an agent which might be used to combat both hormone-dependent and hormone-independent breast cancers, including TNBC, warrants further investigation.
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Dietary cholesterol in graded amounts : threshold to ceiling effects upon plasma free cholesterol synthesis, equilibration and circulation levels in humans
… study was to investigate the effect of dietary cholesterol upon plasma cholesterol concentration and cholesterogenesis; and the aspect of equilibration of newly synthesized cholesterol between plasma and red blood cell (RBC) in humans. Eight healthy subjects (seven men and one woman) at the age …
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Genetic Reduction of Cholesterol Synthesis in the Mouse Brain Does Not Affect Amyloid Formation in an Alzheimer’s Disease Model, but Does Extend Lifespan
In vitro alterations in cellular cholesterol content or synthesis affect the cleavage of amyloid precursor protein (APP) to amyloidogenic peptides characteristic of Alzheimer’s disease (AD). To determine whether a decrease in cholesterol synthesis would affect APP processing in vivo, we crossed …
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Regulation of Cholesterol Biosynthesis in Hepatocytes
Hypercholesterolemia, a condition of high cholesterol levels in the circulation, poses a major risk for developing cardiovascular disease, such as atherosclerosis. A common method of reducing plasma cholesterol levels relies on the administration of drugs that limit cholesterol synthesis or uptake, …
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Regulation of Protein Degradation at the Endoplasmic Reticulum
… Reductase (HMGCR), the rate limiting enzyme in cholesterol biosynthesis. Under sterol rich conditions, HMGCR is rapidly degraded through ERAD, however, when sterols are limited, HMGCR is stabilised through decreased degradation and increased transcription by the transcription factor SREBP2. As …
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Role of Cholesterol 24-Hydroxylase in Hippocampal Long-Term Potentiation
… large percentage of the body's cholesterol, steady-state levels of which are maintained within a narrow range to preserve membrane function. The brain is denied access to circulating lipoproteins by the blood-brain barrier and therefore relies on de novo cholesterol synthesis …
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Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
… (LDL) and related plasma lipoproteins deliver cholesterol to cells by receptor-mediated endocytosis. The lipoprotein is degraded in late endosomes and lysosomes, allowing cholesterol to be released. Export of cholesterol from late endosomes and lysosomes (hereafter referred to as lysosomes) …
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Insulin, Cholesterol and A-beta: Roles and Mechanisms in Alzheimer’s disease
… neuro-inflammation and dysregulation of cholesterol homeostasis, all of which play a role in neuro-degeneration. The main aim of this study was to determine possible relationships between insulin signaling, cholesterol biosynthesis and their effects on Aβ, and inflammatory response in …
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An omics study into the molecular impact of autosomal dominant APP and MAPT mutations on the cerebral cortex
… each iPSC line, I identify an upregulation of cholesterol biosynthesis genes in excitatory and inhibitory neurons and astrocytes carrying MAPT E10+16 mutation compared to the isogenic control cells. I corroborate cholesterol synthesis upregulation in VGLUT1+ excitatory neurons carrying MAPT …
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Lipid Regulation as a Critical Factor in the Development of Alzheimer's Disease
… affecting the regulation of lipids, including cholesterol. In addition to assigning a physiological function for APP and Aβ generation, my hypothesis suggests that lipid dysregulation would likely occur early in the disease process, making it an ideal target for identification of disease risk …
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Roles of cholesterol in the proliferation and differentiation of bovine myoblasts
… role of extracellular, cytosolic, and membrane cholesterol in the proliferation and differentiation of bovine myoblasts. In the first experiment, myoblasts isolated from Angus or Angus crossbred steers were cultured with 2% lipoprotein deficient fetal calf serum (LPDS) or normal fetal calf …
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Investigation of Psychotropic Drugs for the Treatment of Glioblastoma
… drugs indicated that they affect intracellular cholesterol trafficking and the intermediates of the cholesterol synthesis pathway. Furthermore, simvastatin prevented cell migration and seemed to cause cell death through apoptosis. Our in vitro and in vivo studies indicate the potential of these …
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Novel Agonists and Antagonists of Platelet Receptors
… in the mevalonate pathway, i.e. the cholesterol synthesis, we found that one of them, farnesyl pyrophosphate (FPP), had an antagonistic effect on ADP induced platelet activation. Further investigation on FPP with [35S]GTPγS binding and docking studies confirmed that FPP is an …
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A study of the protective effects of an aspalathin enriched green rooibos extract on experimentally induced hepatic steatosis
… revealed that GRT extract regulated fatty acid synthesis by downregulating genes involved in lipogenesis (SREBP 1c and FASN) and glucose metabolism (GCK and ChREBP) as well as inflammation (TNF-α). In db/db mice, GRT improved glucose tolerance and reduced the liver weight to body weight ratio. …
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Effect of aging on metabolic status and hormone responsiveness in the ovary
… membranes, perhaps due to an increase in in vivo cholesterol synthesis with age. Finally, we examined hormone responsiveness of granulosa cells from young and old mares fed a normal hay-based diet or antioxidant-enhanced commericial diet to evaluate hormone responsiveness with aging. Mares fed an …
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SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
Cholesterol synthesis in mammalian cells is highly regulated by an end-product feedback mechanism. The transcription of genes necessary for both fatty acid and cholesterol production are controlled by sterol regulatory element binding proteins (SREBPs). The critical regulatory step is the …
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Wax extraction and characterization from full-fat and defatted rice bran
… alcohols (policosanol) are known to reduce serum cholesterol and inhibit hepatic cholesterol synthesis. The yields and RBWE contents of RBO and RBW extracted from full-fat RB (FFRB) and defatted RB (DFRB) were determined using 6 different conditions with Soxhlet and Microwave-assisted extraction …
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AMPK Regulation of Myeloid Inflammatory Responses During Acute and Chronic Disease
… we examine a downstream target of AMPK in the cholesterol synthesis pathway, HMG-CoA reductase, which has links to the cholesterol-driven pathology of atherosclerosis. By using a combination of mouse and cell models that lack the inhibitory AMPK phosphorylation site on HMG-CoA reductase, we …
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Transcriptome analysis of the hypothalamic-pituitary-adrenal axis in the experimentally domesticated fox
… in addition to genes related to fatty acid and cholesterol synthesis. Variant analysis also implicated cell signaling and exocytosis, as well as ion transport and DNA damage repair. These findings suggest the importance of regulation of hormone release in the control of ACTH and cortisol levels. …
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Characterization of Metabolic Differences in Benign, Slow Developing and Tumor Initiating Ovarian Cancers
… the glycolytic rate and decreased de novo cholesterol synthesis. Cancer stem cells are known to be resistant to chemotherapy treatments and targeting their metabolism may be promising for combinatorial treatments. Therefore, the metabolism of highly aggressive tumor-initiating cells (TIC), …
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