Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"cholesterol metabolism"”.
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Studies on cholesterol metabolism in prostate cancer cells
… studies have associated high blood-cholesterol levels with an increased risk of PCa, whilst cholesterol-lowering drugs (statins) reduce the risk of advanced PCa. Furthermore, PCa cells have been found to accumulate large amounts of cholesterol. Why and how does this happen? This …
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The Complex Association Between Cholesterol Metabolism and Cancer Risk
… system (Roger et al., 2012). Total serum cholesterol levels (TC) have been found to significantly correlate with cardiovascular diseases (Siegel et al., 2012). This has driven researchers to look at possible effects of lipid metabolism on other illnesses, such as cancer. This analysis …
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Cholesterol metabolism in the endoplasmic reticulum of rat liver
… cytochrome P-450 species capable of supporting cholesterol 7a-hydroxylase activity in a reconstituted system, the use of the detergent Renex 690 for the solubilisation of microsomal protein resulted in an unacceptable inhibition of cholesterol 7ct-hydroxylation. This confirmed previous work, …
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Altered Cholesterol Metabolism In Human Cancers Unraveled By Label-Free Spectroscopic Imaging
… targets for human cancers through the study of cholesterol in cancer cells.</p> <p>Enabled by label-free Raman spectromicroscopy, we performed the first quantitative analysis of lipogenesis at single cell level in human patient cancerous tissues. Our imaging data revealed an unexpected, aberrant …
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The effects of dietary protein source on the development of cholesterol metabolism
… of the action that protein source may have on cholesterol levels in infants. The research of this thesis addresses the following questions; (1) do infant formula proteins affect blood lipids in young animals, (2) is there a permanent response of protein consumed during childhood on adult …
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The impact of genetic variation in ABCA1 on cholesterol metabolism, atherosclerosis and diabetes
… member 1 (ABCA1) mediates the major pathway for cholesterol exit from non-hepatic cells and thereby controls the rate-limiting step in the biogenesis of high density lipoprotein (HDL) particles. In humans,ABCA1 deficiency results in Tangier disease, characterized by low levels of HDL cholesterol, …
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ROLE OF LECITHIN:CHOLESTEROL ACYLTRANSFERASE (LCAT) IN BRAIN CHOLESTEROL METABOLISM AND ITS INVOLVEMENT IN ALZHEIMER¿S DISEASE
Cholesterol is an essential component of both peripheral and central nervous system (CNS). Brain cholesterol is synthesized in situ and is almost completely isolated from plasma, but a little fraction can exchange through the blood-brain barrier. The role of esterification in cholesterol metabolism …
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Investigating The Role of Cholesterol Metabolism and Synthesis In Metastasis and Radiation Response In Aggressive Subtypes of Breast Cancer
… treatments. Research has shown diets high in cholesterol increase the incidence of aggressive breast cancers and pre-clinical research has shown cholesterol can fuel the growth of breast cancer in vivo. Studies at MD Anderson have shown that IBC patients taking cholesterol lowering drugs, …
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A Novel Subfamily of Three StAR-Related Lipid Transfer Proteins That Are Differentially-Regulated and Function in Intracellular Cholesterol Metabolism
… decreased three-fold in mice fed a high cholesterol diet. StarD4 also sterol-regulated in cultured cells, and a functional sterol regulatory element (SRE) identified in its promoter. StarD4 was preferentially activated in mouse liver by SREBP-rather than SREBP-1, supporting a role in …
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The Cholesterol Transporter ABCA1 and Cholesterol Accumulation are Key Regulators of Adipose Function in Obesity
… a variety of adipokines that affect whole body metabolism. While much research has focused on adipose storage of TG in the past, this dissertation focuses on cholesterol. Adipocytes can account for up to 50% of the body’s free cholesterol storage, but the effect of cholesterol on adipose tissue, …
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Proteomics of physiologically relevant stresses on model mycobacterium tuberculosis organisms, and the effects on virulence
… of nitric oxide and hydrogen peroxide, cholesterol as a carbon source, as well as nitric oxide in a background of cholesterol as a carbon source. We also performed LC-MS/MS based proteomics to probe the temporal host response to Mycobacterial infection, using murine macrophage cell …
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Metabolic and endocrine aspects of coronary disease
… atherosclerosis. The close relationship of cholesterol metabolism to coronary atherosclerosis and to ischaemic heart disease has been emphasised. The circulating lipids and lipoproteins have been studied in health in relation to age and sex. They were abnormal in the majority of patients …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… like inflammatory bowel disease (IBD) and hypercholesterolemia. We first assessed LOBs and ENL effects on barrier integrity (a pathological hallmark of IBD) in vitro using a monoculture transwell system, and the potential mechanisms involved in maintenance of the barrier. Next, we examined their …
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INVESTIGATING THE ROLE OF DEFECTIVE CELL TO CELL COMMUNICATION MECHANISMS IN RETT SYNDROME PATHOGENESIS
… only exhibit alterations in their morphology, metabolism and calcium signaling, but they also fail to adequately sustain neuronal growth and activity. Although understanding the causative mechanisms could guide the development of novel and effective therapeutic strategies, they remain largely …
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Hyperinsulinemia and Hyperglycemia Contribute to Diabetic Complications Through Cytokine Resistance and Altered Macrophage Function
… have a negative impact on normal macrophage cholesterol metabolism such that under these conditions macrophages are more prone to take up cholesteryl esters. Taken together these findings indicate that the hyperinsulinemic and hyperglycemic conditions associated with type 2 DM produce …
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Prenatal Programming of Hepatic Glucose and Cholesterol Regulation in Male Rat Offspring by Chronic Intermittent Hypoxia
… Adult male CIH offspring were also hypercholesterolemic with decreased expression of LXR target genes associated with cholesterol metabolism and excretion. Taken together, these results describe changes in hepatic function that result in impaired regulation of glucose and cholesterol …
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
<p>Precise regulation of cholesterol levels is necessary for survival of individual cells and the normal functioning of multicellular organisms. Many of the genes important in these processes are regulated at a transcriptional level by the sterol regulatory element binding proteins (SREBPs) and …
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Using biological and chemical information to improve understanding of drug mechanism of action on the systems-level
… across all three methodologies, e.g., cholesterol metabolism modulation, which is a known mediator of tau aggregation. In the final chapter, we developed an R/Shiny app to allow users to carry out integrated chemical structure-based target prediction with gene expression-based causal …
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