Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"cholesterol homeostasis"”.
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Hedgehog Signaling Modulates Cholesterol Homeostasis in Chondrocytes and in Osteoarthritis
… several genes known to be involved in sterol homeostasis were found to be modulated with Hh inhibition. We hypothesized that Hh signaling regulates cholesterol biosynthesis in chondrocytes, and that modulating cholesterol homeostasis impacts the severity of OA. To investigate the function of …
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The Role of Insig-Mediated Cholesterol Homeostasis in Mouse Hair Development
… are indispensable for feedback inhibition of cholesterol biosynthesis. Mice null for both Insigs drastically overproduce cholesterol and its precursor sterol intermediates and exhibit many developmental abnormalities such as cleft palate. In this work, we generate and characterize a line of …
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Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice
Proper cholesterol homeostasis is crucial in mammalian development. Currently, there are 8 known human malformation syndromes due to genetic defects in cholesterol biosynthesis. Patients with these syndromes present with a constellation of developmental defects, ranging from skeletal and …
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Insulin, Cholesterol and A-beta: Roles and Mechanisms in Alzheimer’s disease
… neuro-inflammation and dysregulation of cholesterol homeostasis, all of which play a role in neuro-degeneration. The main aim of this study was to determine possible relationships between insulin signaling, cholesterol biosynthesis and their effects on Aβ, and inflammatory response in …
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Studies on cholesterol metabolism in prostate cancer cells
… studies have associated high blood-cholesterol levels with an increased risk of PCa, whilst cholesterol-lowering drugs (statins) reduce the risk of advanced PCa. Furthermore, PCa cells have been found to accumulate large amounts of cholesterol. Why and how does this happen? This …
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Mutants of Drosophila Melanogaster's ABC Transporter, White, Have Altered Cholesterol-Mediated Acquisition of Memory that is Moderated with 5-HT
… known for their roles in lipid transport and homeostasis. In recent years, several behavioral differences in learning and memory have been found in white mutants that are independent of eye color and associated with 5-HT. This study characterizes a novel defect in the acquisition of olfactory …
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Omics Techniques Applied to Diabetes Research - Focus on HSL-Null Mice and Clonal β-Cells
… in the liver and that HSL influences overall cholesterol homeostasis by indirectly controlling hepatic HDL-cholesterol clearance. We also demonstrated the importance of a cross-talk between white adipose tissue and liver that regulates cholesterol homeostasis via the type of non-esterified …
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Factors affecting the binding of lecithin:cholesterol acyltransferase with interfacial substrates
The esterification of cholesterol on high density lipoproteins (HDL) catalyzed by lecithin:cholesterol acyltransferase (LCAT) maintains a gradient for cholesterol diffusion from cell membranes and atherosclerotic plaques and plays a critical part in the maintenance of cholesterol homeostasis. The …
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Variability of Cholesterol Accessibility in Human Red Blood Cells Measured Using a Bacterial Cholesterol Binding Toxin
Cholesterol partitions into accessible and sequestered pools in cell membranes. Here, we describe a new assay using fluorescently-tagged anthrolysin O, a cholesterol-binding bacterial toxin, to measure accessible cholesterol in human red blood cells (RBCs). Accessible cholesterol levels were stable …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
High blood cholesterol (HBC) is an important risk factor of cardiovascular disease (CVD), which is associated with high morbidity and mortality worldwide. Lifestyle changes and drugs (e.g. statins) are mainly advised by practitioners to manage cholesterol; however, safer alternatives such as …
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Prenatal Programming of Hepatic Glucose and Cholesterol Regulation in Male Rat Offspring by Chronic Intermittent Hypoxia
… Gestational CIH caused impairments in glucose homeostasis, as male CIH offspring were hyperglycemic, hyperinsulinemic, and showed impaired early-stage glucose tolerance in adulthood. Molecular analysis revealed that CIH offspring have diminished regulation of hepatic gluconeogenic pathways by …
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Dual Receptor Uptake of Low-Density Lipoprotein Docosahexaenoic Acid (LDL-DHA) Elicits Differential Sensitivity Across Breast Cancer Subtypes
… compensates for loss of the other to maintain cholesterol homeostasis. Thus, ensuring uptake of LDL-DHA nanoparticles in breast cancer cells. Moreover, LDL-DHA nanoparticles elicit significant cytotoxicity with triple negative breast cancer subtypes being most sensitive to LDL-DHA. As such, in …
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Use of a 3D liver microreactor as an in vitro model for the study of bile acid synthesis and hepatobiliary circulation
… bile acid synthesis, hepatobiliary circulation, cholesterol homeostasis, drug metabolism, etc. This thesis focuses on the use of a 3D in vitro model of liver to study the effects of compounds and culture conditions on hepatobiliary transport and bile acid synthesis. In order to achieve this goal, …
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Biochemical Characterization of Niemann-Pick C: A Disease of Cholesterol Transport
… scientific interest, the mechanism by which cholesterol is transported between membrane compartments in animal cells remains obscure. One transport pathway begins in lysosomes where cholesterol is liberated from plasma lipoproteins that have entered the cell through receptor-mediated …
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Modulation of Mitochondrial Respiration and Metabolic Signalling in Skeletal Muscle by Caveolin-3
… with the plasma membrane as regulators of cholesterol homeostasis and scaffolds for signalling molecules and receptors such as the insulin receptor. Recent work however, has indicated that Cavs can also localise to the membranes of intracellular organelles such as the mitochondria and …
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Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase
… (HMGCR) catalyses the rate-limiting step in the cholesterol biosynthesis pathway and is targeted therapeutically by statins. To maintain cholesterol homeostasis, the expression of HMGCR is tightly regulated by sterols transcriptionally and post-translationally. Sterols induce the association of …
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An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
<p>Regulation of cholesterol levels within cells and organisms is crucial for their survival. Maintenance of cellular cholesterol homeostasis occurs mainly at the transcriptional level, via the Sterol Regulatory Element Binding Proteins (SREBP), the Liver X Receptors (LXR), and the Unfolded Protein …
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The cholesterol efflux protein ABCA1 skews macrophages towards an anti-tumor phenotype and consequently impacts cancer progression
… function can be regulated through disruption in cholesterol metabolism. Additionally, elevated plasma cholesterol levels have been associated with breast cancer recurrence. These findings underscore the impact of cholesterol homeostasis in tumor-associated macrophages on breast cancer …
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Insulin Resistance and Inflammation in Neurodegeneration: Lessons from in vitro Models
… altered expression of transcripts that regulate cholesterol and lipid metabolism. This is important because cholesterol homeostasis is required for efficient neuronal signalling and protein trafficking, and disruption of this balance results in AD-like pathologies. Pericytes are crucial …
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Defining the genetic and molecular pathways underlying motor neuron degenerative diseases
… partner of C6orf120. ERLIN1 is involved in both cholesterol homeostasis and regulation of IP3R degradation which functions as an ER calcium channel and mitochondria-ER tether. Once confirmed the identification of these two disease genes will add to the growing literature implicating …
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