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Showing 1 to 1 of 1 for “"cholestatic itch therapy"”.
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Multiplexed Mapping of the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
… for bile acids and has been implicated in itch in cholestatic liver diseases. Using the SBA assay and a proximity ligation assay, we first showed that MRGPRX4 interacts with RAMPs. We then found that the interaction of MRGPRX4 with RAMP2 causes attenuation of both basal and …