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Showing 1 to 20 of 50 for “"cholera toxin"”.

  1. Functional Characterization Of The Cholera Toxin Promoter Of vibrio Cholerae

    Dittmer, Jennifer2013

    <p> <i>Vibrio cholerae</i> is the bacterium responsible for the severe diarrheal disease cholera. The disease is directly caused by cholera toxin, which is secreted by the bacterium in the upper small intestinal lumen during the course of infection. Expression of cholera toxin, along with other …

    wayne-thes Repository record

  2. Plant-delivered Cholera Toxin B subunit as an Immunomodulatory Molecule

    Arakawa, Takeshi

    <p>The B subunit of cholera toxin (CTB) functions as an effective mucosal carrier molecule of chemically or genetically conjugated antigens. Orally delivered CTB or CTB fusion protein binds to G<sub>M1</sub>-ganglioside receptor molecules located on cells in the gutassociated lymphoid tissues, the …

    loma-linda Repository record

  3. Molecular action of cholera toxin in rabbit intestinal epithelial cells

    Longbottom, DavidThe University of Edinburgh1988

    edinburgh Repository record

  4. Expression Of Cholera Toxin B Subunit-rotavirus Nsp4 Enterotoxin Fusion Protein In Transgenic Chloroplasts

    Kalluri, Anila

    … a peptide, which functions both as a viral enterotoxin and as a factor involved in the acquisition of host cell membrane during virus budding from cells, provides a new approach for mucosal immunization. Protein expression through chloroplast transformation system offers a number of advantages …

    ucf

  5. cholera Toxin B Subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function and T Cell Morphogenesis

    Odumosu, Oludare Jeremiah

    … Ag) to adjuvant molecules such as the non-toxic cholera enterotoxin B subunit (CTB). To identify mechanisms responsible for CTB-autoantigen fusion protein suppression of diabetes autoimmunity, dendritic cells (DCs), a major class of antigen presenting cells (APC) involved in restoration of …

    loma-linda Repository record

  6. Utilization of Cholera Toxin B as an Adjuvant for the Subunit PspA Vaccine, Provides Effective Protection against Streptococcus pneumoniae Challenge

    Pinho, Daniel R.2018

    … and effective protection, this study utilizes Cholera Toxin B (CTB) as an adjuvant to effectively increase vaccine efficacy. We assessed the efficacy of the subunit vaccine, PspA, administered intranasally (i.n.) in conjunction with CTB as an adjuvant. Our results indicated increased survival …

    shu-thes Repository record

  7. Use of Cholera Toxin B as a Vaccine Adjuvant Activates Antigen Presenting Cells and Stimulates Production of Pro-Inflammatory Cytokines

    Romlein, Heather C.2014

    … tularensis</em> (<em>iFt</em>) adjuvanted with Cholera toxin “B” (CTB), successfully granted full protection against a less virulent strain (<em>FT LVS</em>) of the bacterium and provided partial protection against a more virulent strain (SchuS4). However, the mechanisms of this protection are …

    shu-thes Repository record

  8. Plant-based Multicomponent Vaccines against Enteric Diseases

    Yu, Jie

    … plant-based multicomponent oral vaccine against cholera, rotavirus and enterotoxigenic E.coli (ETEC), we have constructed transgenic potato plants that synthesize the cholera toxin B and A2 subunits, the rotavirus enterotoxin NSP4 22 amino acid epitope and the ETEC fimbrial antigen CFA/L To use …

    loma-linda Repository record

  9. Investigation of caveolae-mediated endocytosis in response to interferon

    Yeager, AshleyUniversity of Illinois at Urbana-Champaign2014

    … were used to quantify the internalization of cholera toxin in IFN-treated and untreated cells. Flow cytometry was used to quantify the internalization of fluorescent pathway-specific cholera toxin with established concentrations [6], and the differences between the IFN-treated and untreated …

    uiuc Repository record

  10. 메밀알레르기의 생쥐모델 개발과 비강내 면역요법 후 특이 IgE 생성의 변화

    이, 기선2011

    … Group 3: 25 ㎎/dose of proteins) mixed with cholera toxin as adjuvant. Sham-sensitized(Group 4) mice were sensitized with cholera toxin alone. Naive(Group 5) mice were not sensitized with buckwheat flour or cholera toxin. Three weeks later, mice of Group 1, Group 2, Group 3, and Group 4 were …

    ajou Repository record

  11. Study of Glycan-Mediated Interactions by Photocrosslinking GlcNAc and GalNAc Analogs

    Wu, Han2025

    … of two glycan binding proteins, galectin-1 and cholera toxin B subunit. In addition, I will demonstrate the preliminary results I have on GalNDAz incorporation and photocrosslinking, which indicate that GalNDAz may be incorporated into cellular glycans. Chapter 1 introduces the background of …

    utswmed Repository record

  12. Towards the development of a multicomponent, nanoscale oral vaccine delivery system targeting infectious bursal disease (IBD)

    Pettit, Wendy MarieUniversity of Greenwich2013

    … was fused to a potential carrier protein (cholera toxin B chain), previously shown to mediate the exit from the gut lumen into the lamina propria. However, to allow this antigen to reach the mucosal associated lymphoid tissue, the protein antigen must remain in its native conformation …

    greenwich Repository record

  13. Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6

    Bastien, Jayson I. L.2012

    … delay correlated with reduced trafficking of cholera toxin B-labeled intracellular membranes to the plasma membrane. Cholera toxin-B labels the ganglioside GM1, which is enriched in lipid rafts. These specialized membrane domains are thought to serve as signaling hubs bearing many proteins …

    columbia-diss Repository record

  14. Syntaxin 6- and Microtubule- Mediated Intracellular Trafficking Contributes to Golgi and Nuclear Translocation of Egfr

    Du, Yi2012

    … Interestingly, foreign protein such as bacterial cholera toxin, which is known to activate its pathological function through the Golgi/ER retrograde pathway, also utilizes the MT/Syn6 pathway. Thus, the MT, and syntaxin 6 mediated trafficking pathway from cell surface to the Golgi and ER defines a …

    uthsc Repository record

  15. Investigation of early endosomal sorting and budding

    Barysch, Sina-Victoria2012

    … verschiedene Vesikelinhalte (Transferrin, Cholera Toxin Untereinheit B und LDL, low-density-lipoprotein) voneinander zu trennen. Diese Trennung benötigt sowohl die Bildung von Transportvesikeln, als auch die aktive Reifung von frühen Endosomen. Der Sortier- und Abschnürprozess wird durch …

    goettingen Repository record

  16. The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance

    Esebanmen, Grace Edosewe

    <p>Cholera toxin B subunit fusion to autoantigen vaccines such as proinsulin (CTB-INS) down regulates dendritic cell (DC) activation and induces the synthesis of DC immunosuppressive cytokines. Recent studies of CTB-INS induction of immune tolerance in human DCs indicate that increased IDO1 …

    loma-linda Repository record

  17. SERS-based nanoparticle biodetection using carbohydrate-lectin interactions

    Simpson, Jonathan Robert HenryUniversity of Strathclyde2016

    … lectin and also bacterial lectins including cholera toxin B subunit (CTB). CTB was detected sensitively, selectively and rapidly by using glyconanoparticles coated in a mixture of different carbohydrates (mixed-monolayers of galactose and N-acetylneuraminic acid). Detection was possible in …

    strathclyde Repository record

  18. Intestinal CD4+T Cell Responses to Food

    Lockhart, Ainsley

    … we show that intestinal inflammation induced by cholera toxin (CT) led to increased tissue infiltration of CD4<sup>+</sup> T cells, enriched for Th17 rather than epithelium-adapted cells. Protection against CT-induced food allergy was associated with clonal expansion of Tregs and reduced …

    rockefeller Repository record

  19. Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells

    Mbongue, Jacques Christian

    … proinsulin linked to a mucosal adjuvant the cholera toxin B subunit (CTB-INS). Proteomic analysis of vaccine inoculated DCs revealed strong up-regulation of the tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase (IDO1) shown to be directly linked to CTB-INS-induced DC activation and …

    loma-linda Repository record

  20. TFR Cells Suppress Gut Commensal-Specific IgA Via IL-10

    Abdi, Abdullahi Mohamed2026

    … Bcl6FC) mice with peanut or ovalbumin plus cholera toxin to induce food allergy, collected fecal samples, measured fecal IgA-bound bacteria, and sorted IgA-bound/unbound bacteria for performing 16S sequencing. Additionally, we used adoptive transfer experiments and direct IgA binding assays …

    iupui Repository record

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