Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"cholangiocarcinoma"”.
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Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
Cholangiocarcinoma (CCA) remains a highly aggressive malignancy characterized by poor prognosis and limited response to standard therapies, despite recent advances in drug discovery. This highlights the urgent need for novel and more effective treatment strategies. In the context of precision …
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Investigating the role of primary cilia loss in intrahepatic cholangiocarcinoma
… osmolality. PC malformation has been reported in cholangiocarcinoma (CCA), a neoplasia that originates from these biliary epithelial cells. Despite changes in cilia regulation within CCA, PC-loss alone is insufficient for CCA initiation. However, we show that when PC is deleted from biliary cells …
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Factors affecting recurrence of intrahepatic duct stone and factors affecting development of cholangiocarcinoma after initial treatment of intrahepatic duct stone
… cirrhosis, and is an important risk factor for cholangiocarcinoma, which has a grave prognosis. Nevertheless, its intractable nature and high recurrence rate complicates treatment. Therefore, we investigated factors affecting recurrence of hepatolithiasis and factors affecting development of …
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Combination of CT-based Radiomics Features and Clinical Data for Predicting Tumor Genetic Profile in patients with Intrahepatic Cholangiocarcinoma
Background: Intrahepatic cholangiocarcinoma (iCCA) is an aggressive cancer with increasing incidence, and its genetic alterations may serve as potential targets for systemic therapies. Objective: This study aims to determine whether radiomic features extracted from contrast-enhanced CT scans can …
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Συστηματική ανασκόπηση: αποτελεσματικότητα και ασφάλεια των αναστολέων κινάσης τυροσίνης στο χολαγγειοκαρκίνωμα / Efficacy and safety of tyrosine kinase inhibitors in cholangiocarcinoma: a comprehensive systematic review
Εισαγωγή: Το χολαγγειοκαρκίνωμα (CCA) αποτελεί μία σπάνια κακοήθεια με δυσμενή πρόγνωση και περιορισμένες θεραπευτικές επιλογές στα προχωρημένα στάδια. Οι αναστολείς τυροσινικής κινάσης (TKIs) έχουν αναδυθεί ως στοχευμένη θεραπευτική επιλογή με αυξανόμενο ενδιαφέρον στην ογκολογία, ιδίως σε μοριακά …
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Determining the Oncological and Immunological Effects of Histotripsy for Tumor Ablation
… histotripsy to more fibrotic tumors such as cholangiocarcinoma while sparing nearby critical structures, such as bile ducts and blood vessels. Learning the safety dose-margins from the excised tissues, we performed an in vivo study using mice bearing patient-derived xenograft …
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Clinical and Pathologic Characteristics of Hepatocellular Carcinoma following Resection according to the Tumor Size
… patients with pure HCC (no combined intrahepatic cholangiocarcinoma) underwent first hepatic resection in a single center without preoperative transcatheter arterial chemoembolization (TACE). The 307 patients’ clinicopathologic data were retrospectively investigated. The tumor size criteria (2cm, …
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TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… originates from the biliary tract, including cholangiocarcinoma (CCA) and gallbladder cancer (GBC). In this translational research program targeting BTC, we focus on three aspects: the development of a combination treatment against CCA, the exploration of the immune background of GBC, and the …
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Primary sclerosing cholangitis
… (five from end-stage liver failure and two from cholangiocarcinoma) and two patients underwent liver transplantation. Actuarial survival at five years was 52 per cent. A raised serum bilirubin concentration was the only variable at presentation that independently predicted a poor outcome. …
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Machine learning and data analytics for liver disease modeling
… grounded outcomes, such as the development of cholangiocarcinoma in PSC, predictive performance improves with the integration of multimodal data, particularly targeted bile acid metabolomics. Nonetheless, these predictive models remain limited in interpretability and are not well suited for …
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Defining metabolic zonation as a determinant of hepatocyte plasticity
… described in published studies, intrahepatic cholangiocarcinoma (iCC) was induced via hydrodynamic tail vein delivery of Notch intracellular domain 1 (NICD1) and Akt overexpression, thereby stimulating cell fate change in the two hepatocyte populations of interest. The second approach involved …
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An investigation of insulin-like growth factor binding protein-5 (IGFBP-5) as a biomarker for the detection of early liver disease
… as a tumour marker gene of interhepatic cholangiocarcinoma, a type of cancer of the bile ducts in the liver. This project aims to determine whether IGFBP-5 could be used as a biomarker for detecting liver damage and fibrosis. Several models of liver disease were developed to determine if …