Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"chlorpromazine (CPZ)"”.
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Challenges in method development for analysis of selected phenothizaine drugs in biological samples: oxidation of drugs and metabolites during sample preparation
… of the parent drugs promethazine (PMZ), and chlorpromazine(CPZ) along with selected metabolites promethazine sulfoxide (PMZSO), desmethylpromethazine (DPMZ), chlorpromazine sulfoxide (CPZSO), and desmethylchlorpromazine (DCPZ) in the skeletal remains of rats. We sought to evaluate the …
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Repurposing chlorpromazine and its metabolites for antituberculosis drug discovery
… This study aimed to generate metabolites of chlorpromazine (CPZ), a phenothiazine with demonstrated in vitro activity against Mtb, and to investigate their potential utility in combination with anti-TB drugs. 7-HydroxyCPZ (M2), CPZ-N-oxide (M3), CPZ sulfoxide (M1), nor-CPZ (M5), nor-CPZ …
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The regulation of yeast homotypic membrane fusion by class C ABC transporters
… the bilayer fluidity with the addition of chlorpromazine (CPZ) abolished lipid translocation activity and propranolol inhibition of phosphatidic acid phosphatase activity increased the rate of lipid translocation.
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Lipid composition and membrane physical parameters regulate priming and SNARE function in yeast vacuole membrane fusion
Fusion at highly specialized membrane microdomains is a prerequisite for processes like hormone and neurotransmitter release, antigen presentation and viral infection. Apart from a family of highly conserved proteins called SNAREs, membrane fusion also requires a set of regulatory lipids that …