Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"chloromethyl ketone"”.
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Enzyme activities associated with gonadotropic hormones
… trypsin inhibitor (STI), N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) and to a lesser extent by N-α-p-tosyl-L-lysine chloromethyl ketone (TLCK), which indicated that the observed protease activity was serine protease-like. To establish whether this activity was intrinsic to the hormone or …
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Regulation of tissue levels of metallothionein with emphasis on metallothionein degradation
… Cycloheximide, chloroquine and tosyl-lysine chloromethyl ketone (TLCK) inhibited ³⁵S-MT degradation by 33, 65 and 50%, respectively, without affecting cellular Zn status. Degradation of ³H-protein was inhibited by 41, 41 and 16% in the presence of cycloheximide, chloroquine and TI.CK, …
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An investigation of Porphyromonas gingivalis peptidylarginine deiminase: a putative virulence factor in an animal model of inflammation.
… of the proteolytic inhibitors tosyl phenylalanyl chloromethyl ketone and leupeptin. Tissue sections from three regions of the animal heads were stained for polymorphonuclear cells and osteoclasts. In addition sponge samples were surveyed for polymorphonuclear cells and citrullinated proteins …
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New MRI Techniques for Nanoparticle Based Functional and Molecular Imaging
… i. e. PPACK: D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone) PFC NP, which was postulated to inhibit microvascular coagulation during acute kidney injury. Based on our preliminary 19F MRI findings, we observed that PPACK PFC NP effectively reduced coagulation in our animal model, as …
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Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development
The development of drugs and therapeutic agents for combating infections and human malignancies continues to be a forefront area in both academic and industrial research. This is driven by the rapid emergence of multi-drug resistant bacterial strains and accumulating mutations in cancer targets …