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Showing 1 to 4 of 4 for “"chlorolassin"”.
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Post-translational modifications catalyzed by RiPP and RiPP-adjacent enzymes
… in the biosynthesis of the lasso peptide chlorolassin, in which two of three Trp residues in the final product are modified. Much to our surprise, ChlH modified the linear precursor peptide rather than the mature lasso scaffold. We further endeavored to push this enzyme to its limits, …
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Characterizing peptide-modifying enzyme activity in RiPP biosynthesis
… ChlH, a flavin-dependent halogenase from the chlorolassin lasso peptide biosynthetic pathway. ChlH chlorinates tryptophan residues at internal and terminal positions of an assortment of tested peptide substrates. Systematic mutagenesis of its native substrate peptide reveals a high level of …
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Genomics-Guided Discovery and Characterization of Ancillary RiPP Modifications
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01