Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"chlorin"”.
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Enzymatic activation of cytochrome P-450(cam)
… for the redox activity of the enzyme. Iron chlorin groups, which are partially saturated analogues of protoporphyrin IX, were substituted for the native heme in cytochrome P-450$\sb{\rm cam}$ and also rat liver cytochrome $b\sb5$, which served as a useful model for the more difficult …
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Design, synthesis, and characterization of porphyrin derivatives for biological applications
… studies of novel mono conjugated regioisomers of chlorin e<sub>6</sub> derivatives that are promising photosensitizers for photodynamic therapy. All three regioisomers were synthesized from pheophytin a, which was extracted from the alga Spirulina pacifica. In vitro investigations using human …
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From the Making to the Tuning to the Use of Chlorins for Biomedical Applications
<p>Chlorins are porphyrins missing a double bond. These pigments are optimal platforms for the development of novel dyes that display drug-like attributes such as photodynamic therapy (PDT) agents. More recently, it was demonstrated that chlorins can serve both as a PDT agent and as a modality for …
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Nitrogen isotopes in chlorophyll and the origin of Eastern Mediterranean sapropels
… are presented for the determination of chlorin nitrogen and carbon isotopic ratios in marine particles and sediments with a precision greater than 0.15 per mil for both isotopes. The procedure can be performed in about 4 hours for particulate and 8 hours for sediment samples, and relies …
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The porphynoid pigments of the Caribbean tunicate Trididemnum solidum
Tunichlorin, a nickel chlorin isolated from the Caribbean tunicate Trididemnum solidum, has been identified as nickel (II) 2-devinyl-2-hydroxymethylpyropheophorbide a by chemical and spectroscopic methods. A partial synthesis of dimethyl tunichlorin from chlorophyll a (7 steps, 5% overall yield) …
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Ligand participation in energy storage electrocatalysis and photocatalysis
… and ultimately a doubly-hydrogenated isobacteriochlorin species. The Ni isobacteriochlorin serves as the active hydrogen evolution catalyst, with ring reduction of the ligand necessary to drive metal-hydride formation. A synthetic cobalt chlorin in which the ring reduction is structurally …
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Synthesis of Substituted Bacteriochlorins
… to the macrocycles 3,13-dibromo-5-methoxybacteriochlorin (BC-Br3OMe5Br13) and 3,13-dibromobacteriochlorin (BC-Br3Br13), and second, to functionalize the valuable BC-Br3OMe5Br13 building block. This work improves upon past condensation methods, which afforded low yields of bacteriochlorin with an …
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Tropical climate variability from the last glacial maximum to the present
… in Cariaco Basin is reconstructed using chlorin steryl esters as proxies for phytoplankton community structure. We find that the diatom population was larger during the Younger Dryas cold event, indicating that upwelling was enhanced and the mean position of the ITCZ was farther south …
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ENGINEERING MAGNETIC DEVICE AND NANOPARTICLES PLATFORMS TO IMPROVE DRUG ACCUMULATION AND PENETRATION IN TUMORS FOR ENHANCED CANCER TREATMENT
… constant magnetic gradient. By utilizing Chlorin e6-coated magnetic nanoclusters (Ce6 clusters) with densely packed cobalt-doped superparamagnetic iron oxide nanoparticles for improved magnetic responsiveness, a nearly 3.7-fold increase in tumor accumulation and a 3.5-fold improvement in …
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Nanoparticles and photosensitisers; their interactions and antibacterial properties
… to the thiols were toluidine blue and tin chlorin e6 respectively. It was found gold-tiopronin-toluidine blue nanoparticles at 1 µM concentration were efficient as light activated antimicrobials, that had a reduction of colony forming units (cfu) of S. aureus by 4.5 log 10 compared with, …
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Modifikationen am Photosystem II-Reaktionszentrum
… Mit Porphyrinen (Protochlorophyll) und Bakteriochlorinen konnte kein Austausch festgestellt werden. Die Bindungstasche ist demnach für Pigmente zugänglich, bei denen die Peripherie und/oder das Zentralmetall verändert wurde, während das Chlorinkonjugationssystem erhalten bleiben muss. Das System …
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Trigger-responsive nanomedicines through controlled chemistry
… co-encapsulated with photodynamic sensitizer, chlorin e6, in one NP for combination therapy to combat tumor resistance to photodynamic therapy (PDT) caused by a hypoxic environment. The ultra-high drug loading nanoparticles with controllable release and defined nano-structure mark a milestone …
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Tropical climate variability from the last glacial maximum to the present
… in Cariaco Basin is reconstructed using chlorin steryl esters as proxies for phytoplankton community structure. We find that the diatom population was larger during the Younger Dryas cold event, indicating that upwelling was enhanced and the mean position of the ITCZ was farther south …
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Photodynamic Therapy As An Effective Therapeutic Approach In Mame Models Of Triple Negative And Inflammatory Breast Cancers
… BPD and mono-</p> <p>L-aspartyl chlorin e6 (NPe6), which were sequentially activated. Effects of PDT were assessed</p> <p>by live-dead assays.</p> <p>89</p> <p>Results: Using a MAME model of TNBC and IBC, we demonstrate a significant dose-response</p> <p>in photokilling by …
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Mechanisms associated with Staphylococcus aureus and Acanthamoeba Interactions, and Therapeutic applications"
… Photosensitizers m-Tetra (hydroxyphenyl) chlorin (m-THPC) and psoralen were very effective in eradicating bacteria. In antimicrobial assays, natural product eugenol derivatives demonstrated significant inhibitory activity on the growth of MRSA and exhibited dose-dependent cytotoxic effects …